Evidence map›Paper›PMID 23075455›Full record

ArticleJournal of women's health (2002)2012

Complementary and alternative medicine use and breast cancer prognosis: a pooled analysis of four population-based studies of breast cancer survivors.

Rayna Kim Matsuno, Ian S Pagano, Gertraud Maskarinec, Brian F Issell, Carolyn C Gotay

Registry-linked trialAbstract read
In one paragraph

Article in Journal of women's health (2002), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06137833 (Clinical Study on Wide Spectrum Micronutrients Supplementation in Patients With Cancer Related Fatigue During Neoadjuvant and Adjuvant Chemotherapy), which is not on this map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06137833 narecruitingnot on this mapstarted 2023, after this paper: background citation

Clinical Study on Wide Spectrum Micronutrients Supplementation in Patients With Cancer Related Fatigue During Neoadjuvant and Adjuvant Chemotherapy

TypeinterventionalSponsorPharmanutra S.p.a.Ran2023 to 2025Enrolled92ConditionsFatigue, Breast CancerArmsAPPOPRTAL®, Placebo
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Guideline
  4. Prevalence and frequency of self-management strategies among female cancer survivors: the neglected roles of social relations and conscious living.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rayna Kim MatsunoUniversity of Hawaii Cancer Center, Department of Epidemiology, Honolulu, Hawaii 96813, USA. rweise@cc.hawaii.edu
Ian S Pagano
Gertraud Maskarinec
Brian F Issell
Carolyn C Gotay

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
Nutritional & Behavioral Cancer Prevention in a Multiethnic PopulationR25CA090956 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI MASKARINEC, GERTRAUD · 2002 to 2012
$5.1M
CAM Use in Asians &Pacific IslandersR21AT002218 · NCCIH · UNIVERSITY OF HAWAII AT MANOA · PI GOTAY, CAROLYN COOK · 2005 to 2006
$370k
NCCIH NIH HHS R21 AT002218NCI NIH HHS P30 CA071789NCI NIH HHS R25 CA090956
6 · The paper itself

Abstract

backgroundComplementary and alternative medicine (CAM) use is common among breast cancer survivors, but little is known about its impact on survival.

methodsWe pooled data from four studies conducted in Hawaii in 1994-2003 and linked to the Hawaii Tumor Registry to obtain long-term follow-up information. The effect of CAM use on the risk of breast cancer-specific death was evaluated using Cox regression.

resultsThe analysis included 1443 women with a median follow-up of 11.8 years who had a primary diagnosis of in situ and invasive breast cancer. The majority were Japanese American (36.4%), followed by white (26.9%), Native Hawaiian (15.9%), other (10.6%), and Filipino (10.3%). CAM use was highest in Native Hawaiians (60.7%) and lowest in Japanese American (47.8%) women. Overall, any use of CAM was not associated with the risk of breast cancer-specific death (hazard ratio [HR] 1.47, confidence interval [CI] 0.91-2.36) or all-cause death (HR 0.82, 95% CI 0.63-1.06). However, energy medicine was associated with an increased risk of breast cancer-specific death (HR 3.19, 95% CI 1.06-8.52). When evaluating CAM use within ethnic subgroups, Filipino women who used CAM were at increased risk of breast cancer death (HR 6.84, 95% CI 1.23-38.19).

conclusionsOur findings suggest that, overall, CAM is not associated with breast cancer-specific death but that the effects of specific CAM modalities and possible differences by ethnicity should be considered in future studies.

Indexed as

Cause of DeathSurvivorsAdultAgedAged, 80 and overBreast NeoplasmsComplementary TherapiesConfidence IntervalsEthnicityFemaleFollow-Up StudiesHawaiiHealth SurveysHumansMiddle AgedPatient Acceptance of Health Care

Identifiers

PMID23075455
PMCPMC3810617

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.