ArticleBMC immunology2012
Important role of CCR2 in a murine model of coronary vasculitis.
Article in BMC immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Development and internal validation of a monocyte-to-albumin ratio-based risk assessment model for coronary artery lesions in Kawasaki disease.Frontiers in pediatrics · 2026Article
- Overlapping risk factors and pathogenic mechanisms in lung cancer and cardiovascular disease.Discover oncology · 2025Review
- Emerging evidence of microbial infection in causing systematic immune vasculitis in Kawasaki disease.Frontiers in microbiology · 2023Review
- Intimal macrophages develop from circulating monocytes during vasculitis.Clinical & translational immunology · 2022Article
- Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease.BioMed research international · 2022Article
- The up-to-date pathophysiology of Kawasaki disease.Clinical & translational immunology · 2021Review
- Targeting the Chemokine System in Rheumatoid Arthritis and Vasculitis.JMA journal · 2020Review
- Kawasaki disease: pathophysiology and insights from mouse models.Nature reviews. Rheumatology · 2020Review
- A novel mouse model of coronary stenosis mimicking Kawasaki disease induced by Lactobacillus casei cell wall extract.Experimental animals · 2020Article
- Chemokines in rheumatic diseases: pathogenic role and therapeutic implications.Nature reviews. Rheumatology · 2019Review
- Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis.Arthritis research & therapy · 2019Article
- Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.The Journal of clinical investigation · 2019Article
- Aetiological Significance of Infectious Stimuli in Kawasaki Disease.Frontiers in pediatrics · 2019Review
- A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Losartan attenuates the coronary perivasculitis through its local and systemic anti-inflammatory properties in a murine model of Kawasaki disease.Pediatric research · 2017Article
- Kawasaki disease: a matter of innate immunity.Clinical and experimental immunology · 2016Review
- Regulatory T cells in cardiovascular diseases.Nature reviews. Cardiology · 2016Review
- Histopathological Characteristics of Post-inflamed Coronary Arteries in Kawasaki Disease-like Vasculitis of Rabbits.Acta histochemica et cytochemica · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundChemokines and their receptors play a role in the innate immune response as well as in the disruption of the balance between pro-inflammatory Th17 cells and regulatory T cells (Treg), underlying the pathogenesis of coronary vasculitis in Kawasaki disease (KD).
resultsHere we show that genetic inactivation of chemokine receptor (CCR)-2 is protective against the induction of aortic and coronary vasculitis following injection of Candida albicans water-soluble cell wall extracts (CAWS). Mechanistically, both T and B cells were required for the induction of vasculitis, a role that was directly modulated by CCR2. CAWS administration promoted mobilization of CCR2-dependent inflammatory monocytes (iMo) from the bone marrow (BM) to the periphery as well as production of IL-6. IL-6 was likely to contribute to the depletion of Treg and expansion of Th17 cells in CAWS-injected Ccr2(+/+) mice, processes that were ameliorated following the genetic inactivation of CCR2.
conclusionCollectively, our findings provide novel insights into the role of CCR2 in the pathogenesis of vasculitis as seen in KD and highlight novel therapeutic targets, specifically for individuals resistant to first-line treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.