ArticleProceedings of the National Academy of Sciences of the United States of America2012
Readily releasable pool of synaptic vesicles measured at single synaptic contacts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Estimates of quantal synaptic parameters in light of more complex vesicle pool models.Frontiers in cellular neuroscience · 2025Article
- A maximum of two readily releasable vesicles per docking site at a cerebellar single active zone synapse.eLife · 2024Article
- Extreme value statistics of nerve transmission delay.PloS one · 2024Article
- Three small vesicular pools in sequence govern synaptic response dynamics during action potential trains.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Differentially poised vesicles underlie fast and slow components of release at single synapses.The Journal of general physiology · 2020Article
- Incomplete vesicular docking limits synaptic strength under high release probability conditions.eLife · 2020Article
- Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:CaeLife · 2020Article
- Synaptic Vesicles Dynamics in Neocortical Epilepsy.Frontiers in cellular neuroscience · 2020Article
- Homeostatic Plasticity in Epilepsy.Frontiers in cellular neuroscience · 2020Article
- Zebrafish neuromuscular junction: The power of N.Neuroscience letters · 2019Review
- What We Can Learn From Cumulative Numbers of Vesicular Release Events.Frontiers in cellular neuroscience · 2019Article
- The Small and Dynamic Pre-primed Pool at the Release Site; A Useful Concept to Understand Release Probability and Short-Term Synaptic Plasticity?Frontiers in synaptic neuroscience · 2019Review
- A two-step docking site model predicting different short-term synaptic plasticity patterns.The Journal of general physiology · 2018Article
- Photolysis of a Caged, Fast-Equilibrating Glutamate Receptor Antagonist, MNI-CagedFrontiers in cellular neuroscience · 2018Article
- Kinetics of transmitter release at the calyx of Held synapse.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Numbers of presynaptic CaProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Synaptic reliability and temporal precision are achieved via high quantal content and effective replenishment: auditory brainstem versus hippocampus.The Journal of physiology · 2017Article
- Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Synapse-Level Determination of Action Potential Duration by K(+) Channel Clustering in Axons.Neuron · 2016Article
- Counting Vesicular Release Events Reveals Binomial Release Statistics at Single Glutamatergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To distinguish between different models of vesicular release in brain synapses, it is necessary to know the number of vesicles of transmitter that can be released immediately at individual synapses by a high-calcium stimulus, the readily releasable pool (RRP). We used direct stimulation by calcium uncaging at identified, single-site inhibitory synapses to investigate the statistics of vesicular release and the size of the RRP. Vesicular release, detected as quantal responses in the postsynaptic neuron, showed an unexpected stochastic variation in the number of quanta from stimulus to stimulus at high intracellular calcium, with a mean of 1.9 per stimulus and a maximum of three or four. The results provide direct measurement of the RRP at single synaptic sites. They are consistent with models in which release proceeds from a small number of vesicle docking sites with an average occupancy around 0.7.
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