ArticleProceedings of the National Academy of Sciences of the United States of America2012
Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 189 citations in OpenAlex.
- Feasibility of longitudinal in vivo monitoring of pulmonary disease progression in mouse models using laboratory-based x-ray dark-field CT.European radiology experimental · 2026Article
- Moiré fringes of photon counting grating interferometer with single-focal-spot and flat-panel X-ray sources.Medical physics · 2026Article
- The lung in acute respiratory failure: insights from synchrotron radiation imaging.Intensive care medicine experimental · 2026Review
- Beam-hardening correction in clinical x-ray dark-field chest radiography using deep-learning-based bone segmentation.Medical physics · 2026Article
- High-energy X-ray phase-contrast CT of an adult human chest phantom.Scientific reports · 2025Article
- Dark-field chest radiography signal characteristics in inspiration and expiration in healthy and emphysematous subjects.European radiology experimental · 2025Article
- Comparison of dark-field chest radiography and CT for the assessment of COVID-19 pneumonia.Frontiers in radiology · 2024Article
- [Dark-field imaging and computed tomography : Novel X-ray-based contrast imaging modality with great promise for pulmonary imaging].Radiologie (Heidelberg, Germany) · 2023Review
- Edge-Illumination X-Ray Dark-Field Tomography.Physical review applied · 2023Article
- Multimodal intrinsic speckle-tracking (MIST) to extract images of rapidly-varying diffuse X-ray dark-field.Scientific reports · 2023Article
- The choice of an autocorrelation length in dark-field lung imaging.Scientific reports · 2023Article
- Tuberculosis conundrum - current and future scenarios: A proposed comprehensive approach combining laboratory, imaging, and computing advances.World journal of radiology · 2022Review
- Article
- X-ray dark field imaging: a tool for early diagnosis of emphysema in chronic obstructive pulmonary disease?The Lancet. Digital health · 2021Article
- X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.The Lancet. Digital health · 2021Article
- In-vivo X-ray dark-field computed tomography for the detection of radiation-induced lung damage in mice.Physics and imaging in radiation oncology · 2021Article
- X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study.Scientific reports · 2021Article
- Quantitative analysis of speckle-based X-ray dark-field imaging using numerical wave-optics simulations.Scientific reports · 2021Article
- High-resolution multicontrast tomography with an X-ray microarray anode-structured target source.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Whole-body x-ray dark-field radiography of a human cadaver.European radiology experimental · 2021Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
Abstract
In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.