ReviewStem cells (Dayton, Ohio)2013
Concise review: Defining characteristics of mammalian spermatogenic stem cells.
Review in Stem cells (Dayton, Ohio), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- In Vitro Generation of Haploid Germ Cells from Human XY and XXY Immature Testes in a 3D Organoid System.Bioengineering (Basel, Switzerland) · 2024Article
- Introduction: The Why's and How's for Studying Spermatogenesis and Spermatogonial Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Role of the Ubiquitin Ligase RNF149 in the Development of Rat Neonatal Gonocytes.Frontiers in endocrinology · 2022Article
- Epigenetic transgenerational inheritance, gametogenesis and germline development†.Biology of reproduction · 2021Review
- Antioxidant or Apoptosis Inhibitor Supplementation in Culture Media Improves Post-Thaw Recovery of Murine Spermatogonial Stem Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Therapeutic miRNA-Enriched Extracellular Vesicles: Current Approaches and Future Prospects.Cells · 2020Review
- Spermatogonial Stem Cells for In Vitro Spermatogenesis and In Vivo Restoration of Fertility.Cells · 2020Review
- A bioenergetic shift is required for spermatogonial differentiation.Cell discovery · 2020Article
- Association Study of Puberty-Related Candidate Genes in Chinese Female Population.International journal of genomics · 2020Article
- Study of Tnp1, Tekt1, and Plzf Genes Expression During an in vitro Three-Dimensional Neonatal Male Mice Testis CultureIranian biomedical journal · 2018Article
- The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.Stem cell reports · 2017Article
- Hormone-sensitive lipase deficiency alters gene expression and cholesterol content of mouse testis.Reproduction (Cambridge, England) · 2017Article
- Characterizing the Spermatogonial Response to Retinoic Acid During the Onset of Spermatogenesis and Following Synchronization in the Neonatal Mouse Testis.Biology of reproduction · 2016Article
- Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers.Annual review of genomics and human genetics · 2016Review
- Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation.Cell death and differentiation · 2016Article
- Chemokine (C-X-C) Ligand 12 Facilitates Trafficking of Donor Spermatogonial Stem Cells.Stem cells international · 2016Article
- Retracted article: In vitro derivation of mammalian germ cells from stem cells and their potential therapeutic application.Cellular and molecular life sciences : CMLS · 2015Article
- Id4 Marks Spermatogonial Stem Cells in the Mouse Testis.Scientific reports · 2015Article
- Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential.BMC cancer · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The enormous number of sperms produced daily and over the lifetime of mammals requires a stable source of stem cells that give rise to progenitor cells that proceed through spermatogenesis. Spermatogenic stem cells develop from primitive germ cells that occupy the developing gonad. A transplantation assay was developed for the spermatogenic stem cells, and it remains the only functional measure of authentic stem cells in the testis. Somatic cells comprise a "niche" environment that is essential for the maintenance of stem cell activity. Dividing progenitor cells have intercellular bridges and form syncytia with 2, 4, 8, or 16 cells. Fragmentation of these syncytia may allow some progenitor cells to occupy "niches" and function as stem cells, but this notion requires further investigation. Spermatogenic stem cells can be maintained in culture and are influenced by a number of growth factors. Thus far, the ultimate differentiation of cultured stem cells into functional gametes has not been demonstrated with any efficiency and reproducibility. The ability to maintain spermatogenic stem cells in culture and to induce differentiation into haploid cells and sperm could have many important implications for human medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.