ReviewEuropean journal of applied physiology2013
Maximizing information from space data resources: a case for expanding integration across research disciplines.
Review in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Biological clocks and blood clots in space: circadian disruption-induced modulation of thrombosis risk.Research and practice in thrombosis and haemostasis · 2026Pooled it
- Effect of computerized cognitive training with virtual spatial navigation task during bed rest immobilization and recovery on vascular function: a pilot study.Clinical interventions in aging · 2015Trial
- Network physiology in space: vision and perspectives on exploring physiological networks during spaceflight for the benefit of life on earth.Frontiers in network physiology · 2026Article
- Internal jugular venous flow responses to graded lower body negative pressure: a sex-stratified analysis.Frontiers in physiology · 2026Article
- A combined individualized cycling exercise and artificial gravity training protocol as a spaceflight deconditioning countermeasure.NPJ microgravity · 2025Article
- Repeatability of artificial gravity tolerance times.Frontiers in physiology · 2025Article
- Article
- Validating Causal Diagrams of Human Health Risks for Spaceflight: An Example Using Bone Data from Rodents.Biomedicines · 2022Article
- Database of space life investigations and bioinformatics of microbiology in extreme environments.Frontiers in microbiology · 2022Article
- Canadian aging and inactivity study: Spaceflight-inspired exercises during head-down tilt bedrest blunted reductions in muscle-pump but not cardiac baroreflex in older persons.Frontiers in physiology · 2022Article
- Effects of space flight on sperm function and integrity: A systematic review.Frontiers in physiology · 2022Review
- Effect of Microgravity Environment on Gut Microbiome and Angiogenesis.Life (Basel, Switzerland) · 2021Article
- Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth.NPJ microgravity · 2021Review
- Alterations in Cerebral Hemodynamics During Microgravity: A Literature Review.Medical science monitor : international medical journal of experimental and clinical research · 2021Review
- Fluid Shifts Induced by Physical Therapy in Lower Limb Lymphedema Patients.Journal of clinical medicine · 2020Article
- Effect of novel short-arm human centrifugation-induced gravitational gradients upon cardiovascular responses, cerebral perfusion and g-tolerance.The Journal of physiology · 2020Article
- Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization.Scientific reports · 2020Article
- A systematic review and meta-analysis of bone loss in space travelers.NPJ microgravity · 2020Article
- The effects of varying gravito-inertial stressors on grip strength and hemodynamic responses in men and women.European journal of applied physiology · 2019Article
- The Behavioral Biology of Teams: Multidisciplinary Contributions to Social Dynamics in Isolated, Confined, and Extreme Environments.Frontiers in psychology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory systems are affected in space by exposure to weightlessness, high-energy radiation or other spaceflight-induced changes. The impact of spaceflight occurs across multiple scales and systems. Exploring such interactions and interdependencies via an integrative approach provides new opportunities for elucidating these complex responses. This paper argues the case for increased emphasis on integration, systematically archiving, and the coordination of past, present and future space and ground-based analogue experiments. We also discuss possible mechanisms for such integration across disciplines and missions. This article then introduces several discipline-specific reviews that show how such integration can be implemented. Areas explored include: adaptation of the central nervous system to space; cerebral autoregulation and weightlessness; modelling of the cardiovascular system in space exploration; human metabolic response to spaceflight; and exercise, artificial gravity, and physiologic countermeasures for spaceflight. In summary, spaceflight physiology research needs a conceptual framework that extends problem solving beyond disciplinary barriers. Administrative commitment and a high degree of cooperation among investigators are needed to further such a process. Well-designed interdisciplinary research can expand opportunities for broad interpretation of results across multiple physiological systems, which may have applications on Earth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.