ArticleMolecular biology reports2013
Comparative analysis of differentially expressed genes in Sika deer antler at different stages.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Integrated mRNA and miRNA Analysis Reveals Layer-Specific Mechanisms of Antler Yield Variation in Sika Deer.Animals : an open access journal from MDPI · 2025Article
- Gene expression supports a single origin of horns and antlers in hoofed mammals.Communications biology · 2024Article
- The Genetic Basis Underpinning Sexually Selected Traits across Different Animal Lineages: Are There Genetic Mechanisms in Common?Animals : an open access journal from MDPI · 2024Review
- MiRNA Profiling and Its Potential Roles in Rapid Growth of Velvet Antler in Gansu Red Deer (Genes · 2023Article
- Evaluation of candidate reference genes for quantitative real-time PCR normalization in blood from red deer developing antlers.Scientific reports · 2022Article
- Identification and Characterization of Alternative Splicing Variants and Positive Selection Genes Related to Distinct Growth Rates of Antlers Using Comparative Transcriptome Sequencing.Animals : an open access journal from MDPI · 2022Article
- Integrative Analyses of Antler Cartilage Transcriptome and Proteome of Gansu Red Deer (Animals : an open access journal from MDPI · 2022Article
- Comparative antler proteome of sika deer from different developmental stages.Scientific reports · 2021Article
- Comparative transcriptome analysis of the main beam and brow tine of sika deer antler provides insights into the molecular control of rapid antler growth.Cellular & molecular biology letters · 2020Article
- Analysis of genetic information from the antlers of Rangifer tarandus (reindeer) at the rapid growth stage.PloS one · 2020Article
- Full-length transcriptome and microRNA sequencing reveal the specific gene-regulation network of velvet antler in sika deer with extremely different velvet antler weight.Molecular genetics and genomics : MGG · 2019Article
- Identification of the miRNA-mRNA regulatory network of antler growth centers.Journal of biosciences · 2019Article
- Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq.Stem cell research & therapy · 2018Article
- Illumina-based de novo transcriptome sequencing and analysis of Chinese forest musk deer.Journal of genetics · 2017Article
- Transcriptome analysis of sika deer in China.Molecular genetics and genomics : MGG · 2016Article
- Detoxification strategies and regulation of oxygen production and flowering of Platanus acerifolia under lead (Pb) stress by transcriptome analysis.Environmental science and pollution research international · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deer antlers serve as useful models of rapid growth and mineralization in mammals. During the period of rapid growth, the antlers of many species of deer will elongate by more than 2 cm per day, after which the antlers gradually ossify. However, little is known about the genes that are involved in their development, particularly the molecular mechanisms responsible for rapid growth and ossification. In our previous studies, we have reported on the transcriptome analysis of deer antlers at rapid growth and ossification stages. With the aim to get a comprehensive understanding of gene expression patterns during antler growth, in the present study, we performed a rigorous algorithm to identify differentially expressed genes between two different stages (60 and 90 days) during antler growth. A total of 16,905 significantly changed transcripts were identified. Those sequences were mapped to 5,573 genes with 2,217 genes up-regulated and 3,356 genes down-regulated (60 days vs. 90 days), including ribosomal proteins, translation initiation and elongation factors, transcription factors, signaling molecules and extracellular matrix proteins. We also performed the gene ontology (GO) functional enrichment and pathway enrichment analysis of gene expression patterns with hypergeometric test and Bonferroni Correction. Both the two stages were enriched with members of GO categories and distinct pathways. Our data represent the most comprehensive sequence resource available for the deer antler and provide a basis for further research on deer antler molecular genetics and functional genomics.
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