ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2012
Perturbation of the transforming growth factor β system in Turner syndrome.
Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- The Hypothesis of the Prolonged Cell Cycle in Turner Syndrome.Journal of developmental biology · 2022Review
- Turner's syndrome associated with discoid lateral meniscus and Blount's disease: a case report.BMC musculoskeletal disorders · 2021Article
- Magnetic resonance imaging 4-D flow-based analysis of aortic hemodynamics in Turner syndrome.Pediatric radiology · 2017Article
- Genetic and Developmental Basis of Cardiovascular Malformations.Clinics in perinatology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo measure components of the circulating transforming growth factor β (TGFβ) system in patients with Turner syndrome (TS) compared to relevant controls and to ascertain correlation with endocrine and cardiovascular parameters.
methodsTGFβ1, TGFβ2 and endoglin (a vascular TGF receptor component) were measured using enzyme-linked immunoassays in the sera of 40 subjects with TS and 40 healthy volunteer women. The cardiovascular phenotype in TS subjects was extensively characterized by cardiac magnetic resonance (MR) and echo.
resultsTGFβ1 levels were about 3-fold higher in TS while TGFβ2 levels were about 3.5-fold higher in controls (P<0.000 1 for both). Soluble endoglin levels were 25% higher in TS (P<0.000 1). Variation in TGFβ system components was not explained by age, blood pressure, platelet count, thyroid function, body proportions or cardiovascular phenotype.
conclusionThere is profound perturbation of the TGFβ system evident in the circulation of individuals with TS.
Indexed as
Identifiers
23073581PMC6544142W2347678399What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.