Trial reportMedicine and science in sports and exercise2013
Acute effects of exercise and calorie restriction on triglyceride metabolism in women.
Trial report in Medicine and science in sports and exercise, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Moderate intensity aerobic exercise during pregnancy and 1-month infant Morphometry.Birth defects research · 2021Trial
- Lipoprotein Subclass Profile after Progressive Energy Deficits Induced by Calorie Restriction or Exercise.Nutrients · 2018Trial
- One day of mixed meal overfeeding reduces hepatic insulin sensitivity and increases VLDL particle but not VLDL-triglyceride secretion in overweight and obese men.The Journal of clinical endocrinology and metabolism · 2013Trial
- High-Intensity Interval Training Enhances Cardiovascular and Functional Outcomes Compared With Moderate-Intensity Continuous Training in Higher-Functioning Chronic Stroke.Annals of rehabilitation medicine · 2025Article
- Review
- Lipid-based Nutritional Supplement Impact on Energy Intake, Appetite, Glucose and Insulin Levels in Under-Weight Pregnant and Lactating Women with Preeclampsia.Bioscience reports · 2024Article
- Men and women display distinct extracellular vesicle biomarker signatures in response to military operational stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Comparison of Acute Cardiometabolic Responses in a 7-Minute Body Weight Circuit to 7-Minute HIIT Training Protocol.International journal of exercise science · 2020Article
- Effects of exercise training on intrahepatic lipid content in humans.Diabetologia · 2016Review
- Postprandial lipemic and inflammatory responses to high-fat meals: a review of the roles of acute and chronic exercise.Nutrition & metabolism · 2016Review
- The childhood obesity epidemic as a result of nongenetic evolution: the maternal resources hypothesis.Mayo Clinic proceedings · 2015Article
- Intensity-dependent and sex-specific alterations in hepatic triglyceride metabolism in mice following acute exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Sexual dimorphism in the effects of exercise on metabolism of lipids to support resting metabolism.Frontiers in endocrinology · 2014Review
- Exercise and dietary-mediated reductions in postprandial lipemia.Journal of nutrition and metabolism · 2014Review
- The latest on the effect of prior exercise on postprandial lipaemia.Sports medicine (Auckland, N.Z.) · 2013Review
- Effect of acute negative and positive energy balance on basal very-low density lipoprotein triglyceride metabolism in women.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThe mechanisms by which exercise reduces fasting plasma triglyceride (TG) concentrations in women and the effect of negative energy balance independent of muscular contraction are not known.The aim of this study was to evaluate the effects of equivalent energy deficits induced by exercise or calorie restriction on basal VLDL-TG metabolism in women.
methodsEleven healthy women (age = 23.5 ± 2.7 yr, body mass index = 21.6 ± 1.4 kg·m-2; mean ± SD) underwent a stable isotopically labeled tracer infusion study to determine basal VLDL-TG kinetics after performing, in random order, three experimental trials on the previous day: (i) a single exercise bout (brisk walking at 60% of peak oxygen consumption for 123 ± 18 min, with a net energy expenditure of 2.06 ± 0.39 MJ, ∼500 kcal), (ii) dietary energy restriction of 2.10 ± 0.41 MJ, and (iii) a control day of isocaloric feeding and rest (zero energy balance).
resultsFasting plasma VLDL-TG concentration was approximately 30% lower after the exercise trial compared with the control trial (P < 0.001), whereas no significant change was detected after the calorie restriction trial (P = 0.297 vs control). Relative to the control condition, exercise increased the plasma clearance rate of VLDL-TG by 22% (P = 0.001) and reduced hepatic VLDL-TG secretion rate by approximately 17% (P = 0.042), whereas hypocaloric diet had no effect on VLDL-TG kinetics (P > 0.2).
conclusion(i) Exercise-induced hypotriglyceridemia in women manifests through a different mechanism (increased clearance and decreased secretion of VLDL-TG) than that previously described in men (increased clearance of VLDL-TG only), and (ii) exercise affects TG homeostasis by eliciting changes in VLDL-TG kinetics that cannot be reproduced by an equivalent diet-induced energy deficit, indicating that these changes are independent of the exercise-induced negative energy balance but instead are specific to muscular contraction.
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