ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
A role for the prefrontal cortex in heroin-seeking after forced abstinence by adult male rats but not adolescents.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Neuronal Grin2c expression and the cocaine engram: a medial prefrontal cortex substrate for conditioned place preference.bioRxiv : the preprint server for biology · 2026Article
- Uncovering phenotypic diversity and cell-type-specific prefrontal cortex calcium dynamics in rat fentanyl self-administration.bioRxiv : the preprint server for biology · 2026Article
- Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction.Biological psychiatry · 2025Article
- Dissociation of intake and incentive sensitization during intermittent- and continuous-access heroin self-administration in rats.Psychopharmacology · 2025Article
- Brain microRNA profiles after exposure to heroin in rats.Experimental brain research · 2024Article
- Environmental Enrichment during Abstinence Reduces Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial Prefrontal Cortex Neurons.Drug and alcohol dependence · 2024Article
- Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Sex/Gender Differences in the Time-Course for the Development of Substance Use Disorder: A Focus on the Telescoping Effect.Pharmacological reviews · 2023Review
- Fos-expressing neuronal ensembles in rat infralimbic cortex encode initial and maintained oxycodone seeking in rats.Addiction biology · 2022Article
- Factors modulating the incubation of drug and non-drug craving and their clinical implications.Neuroscience and biobehavioral reviews · 2021Review
- Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence.Scientific reports · 2021Article
- Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models.Current research in neurobiology · 2021Review
- Incubation of Oxycodone Craving Following Adult-Onset and Adolescent-Onset Oxycodone Self-Administration in Male Rats.Frontiers in behavioral neuroscience · 2021Article
- Repeated blast model of mild traumatic brain injury alters oxycodone self-administration and drug seeking.The European journal of neuroscience · 2019Article
- Sex-dependent regulation of social reward by oxytocin receptors in the ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Relapse to opioid seeking in rat models: behavior, pharmacology and circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Role of oxytocin in the ventral tegmental area in social reinforcement.Psychoneuroendocrinology · 2018Article
- Reduced sensitivity to reinforcement in adolescent compared to adult Sprague-Dawley rats of both sexes.Psychopharmacology · 2018Article
- Role of Central Amygdala Neuronal Ensembles in Incubation of Nicotine Craving.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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3 authors.
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Abstract
Adolescent drug abuse is hypothesized to increase the risk of drug addiction. Yet male rats that self-administer heroin as adolescents show attenuated drug-seeking after abstinence, compared with adults. Here we explore a role for neural activity in the medial prefrontal cortex (mPFC) in age-dependent heroin-seeking. Adolescent (35-day-old at start; adolescent-onset) and adult (86-day-old at start) male rats acquired lever-pressing maintained by heroin using a fixed ratio one reinforcement schedule (0.05 and 0.025 mg/kg per infusion). Following 12 days of forced abstinence, rats were tested for heroin-seeking over 1 h by measuring the number of lever presses on the active lever. Unbiased stereology was then used to estimate the number of Fos-ir(+) and Fos-ir(-) neurons in prelimbic and infralimbic mPFC. As before, adolescents and adults self-administered similar amounts of heroin, but subsequent heroin-seeking was attenuated in the younger rats. Similarly, the adolescent-onset group failed to show significant neural activation in the prelimbic or infralimbic mPFC during the heroin-seeking test, whereas the adult-onset heroin self-administration group showed two to six times more Fos-ir(+) neurons than their saline counterparts in both mPFC subregions. Finally, the overall number of neurons in the infralimbic cortex was greater in rats from the adolescent-onset groups than adults. The mPFC may thus have a key role in some age-dependent effects of heroin self-administration.
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