ArticleResearch in microbiology2013
Mutation of crp mediates Serratia marcescens serralysin and global secreted protein production.
Article in Research in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
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- Increased Proteolytic Activity ofPolish journal of microbiology · 2024Article
- A rise in the frequency ofFrontiers in cellular and infection microbiology · 2023Article
- IgaA Protein, GumB, Has a Global Impact on the Transcriptome and Surface Proteome of Serratia marcescens.Infection and immunity · 2022Article
- Differential susceptibility of airway and ocular surface cell lines to FlhDC-mediated virulence factors PhlA and ShlA fromJournal of medical microbiology · 2021Article
- Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells.PLoS pathogens · 2019Article
- EepR Mediates Secreted-Protein Production, Desiccation Survival, and Proliferation in a Corneal Infection Model.Infection and immunity · 2015Article
- Putting on the brakes: Bacterial impediment of wound healing.Scientific reports · 2015Article
- Serratia marcescens Cyclic AMP Receptor Protein Controls Transcription of EepR, a Novel Regulator of Antimicrobial Secondary Metabolites.Journal of bacteriology · 2015Article
- Identification of SlpB, a Cytotoxic Protease from Serratia marcescens.Infection and immunity · 2015Article
- Molecular characterization of protease activity in Serratia sp. strain SCBI and its importance in cytotoxicity and virulence.Journal of bacteriology · 2014Article
- Cyclic-AMP inhibition of fimbriae and prodigiosin production by Serratia marcescens is strain-dependent.Archives of microbiology · 2014Article
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- SlpE is a calcium-dependent cytotoxic metalloprotease associated with clinical isolates of Serratia marcescens.Research in microbiologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The bacterial species Serratia marcescens secretes both beneficial and cytotoxic proteins. Here we report that a crp mutant exhibited elevated secreted protease activity. A genetic screen revealed that the gene coding for the metalloprotease serralysin was necessary for the elevated proteolysis, and this was confirmed by western blot analysis. Proteomic analysis of secreted proteins corroborated increased secretion of serralysin protease by crp mutants compared to the wild type. The crp-mutant-secreted fractions also contained less chitinase and chitin binding protein. These data support the hypothesis that cAMP-CRP is an upstream indirect regulator of serralysin production and they provide novel insight into the S. marcescens secretome.
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