ReviewTissue engineering. Part B, Reviews2013
Bioreactor design for tendon/ligament engineering.
Review in Tissue engineering. Part B, Reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review).International journal of molecular medicine · 2026Review
- Humanoid Robotic Loading Enhances Mechanotransduction in Tendon Tissue Engineering.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Advances in Achilles Tendon Tissue Engineering: Integrating Cells, Scaffolds, and Mechanical Loading for Functional Regeneration.Bioengineering (Basel, Switzerland) · 2025Review
- Fibrin Scaffolds Perfused with Transforming Growth Factor-β1 as an In Vitro Model to Study Healthy and Tendinopathic Human Tendon Stem/Progenitor Cells.International journal of molecular sciences · 2024Article
- Design and construction of a low-cost compressive loading and perfusion flow bioreactor.HardwareX · 2024Article
- Collagen scaffold-seeded iTenocytes accelerate the healing and functional recovery of Achilles tendon defects in a rat model.Frontiers in bioengineering and biotechnology · 2024Article
- Equine tendon mechanical behaviour: Prospects for repair and regeneration applications.Veterinary medicine and science · 2023Review
- Development of three-layer collagen scaffolds to spatially direct tissue-specific cell differentiation for enthesis repair.Materials today. Bio · 2023Article
- Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalentsBiomaterials and biosystems · 2022Article
- Advanced Gene Therapy Strategies for the Repair of ACL Injuries.International journal of molecular sciences · 2022Review
- Wetspun Polymeric Fibrous Systems as Potential Scaffolds for Tendon and Ligament Repair, Healing and Regeneration.Pharmaceutics · 2022Review
- Humanoid robots to mechanically stress human cells grown in soft bioreactors.Communications engineering · 2022Article
- Modular Bioreactor Design for Directed Tendon/Ligament Tissue Engineering.Bioengineering (Basel, Switzerland) · 2022Article
- Review
- Advanced Robotics to Address the Translational Gap in Tendon Engineering.Cyborg and bionic systems (Washington, D.C.) · 2022Review
- Reduction of mechanical loading in tendons induces heterotopic ossification and activation of the β-catenin signaling pathway.Journal of orthopaedic translation · 2021Article
- Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.Advanced healthcare materials · 2021Review
- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life.Advances in experimental medicine and biology · 2021Review
- A brief history of tendon and ligament bioreactors: Impact and future prospects.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- In Vitro Innovation of Tendon Tissue Engineering Strategies.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendon and ligament injury is a worldwide health problem, but the treatment options remain limited. Tendon and ligament engineering might provide an alternative tissue source for the surgical replacement of injured tendon. A bioreactor provides a controllable environment enabling the systematic study of specific biological, biochemical, and biomechanical requirements to design and manufacture engineered tendon/ligament tissue. Furthermore, the tendon/ligament bioreactor system can provide a suitable culture environment, which mimics the dynamics of the in vivo environment for tendon/ligament maturation. For clinical settings, bioreactors also have the advantages of less-contamination risk, high reproducibility of cell propagation by minimizing manual operation, and a consistent end product. In this review, we identify the key components, design preferences, and criteria that are required for the development of an ideal bioreactor for engineering tendons and ligaments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.