ArticleBiology of sex differences2012
Gender, anthropometric factors and risk of colorectal cancer with particular reference to tumour location and TNM stage: a cohort study.
Article in Biology of sex differences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Adult-Attained Height and Colorectal Cancer Risk: A Cohort Study, Systematic Review, and Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies.Oncotarget · 2017Pooled it
- Body mass index and colorectal cancer prognosis: a systematic review and meta-analysis.Techniques in coloproctology · 2016Pooled it
- Adiposity and risks of gastrointestinal cancers: A 10-year prospective study of 0.5 million Chinese adults.International journal of cancer · 2025Article
- Risk of colorectal adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer; a nationwide cohort study.Cancer causes & control : CCC · 2023Article
- Influence of colonic mesenteric area on the number of lymph node retrieval for colon cancer: a prospective cohort study.Annals of coloproctology · 2023Article
- Assessment of Body Mass Index, Polygenic Risk Score, and Development of Colorectal Cancer.JAMA network open · 2022Article
- Impact of Preoperative Visceral Fat Area Measured by Bioelectrical Impedance Analysis on Clinical and Oncologic Outcomes of Colorectal Cancer.Nutrients · 2022Article
- A model of weight-based stigma in health care and utilization outcomes: Evidence from the learning health systems network.Obesity science & practice · 2022Article
- The Impact of Body Mass Index on the Clinicopathological and Prognostic Factors of Colorectal Cancer in Saudi Arabia.Cureus · 2020Article
- Risk Factor Profiles Differ for Cancers of Different Regions of the Colorectum.Gastroenterology · 2020Article
- Long-term status of predicted body fat percentage, body mass index and other anthropometric factors with risk of colorectal carcinoma: Two large prospective cohort studies in the US.International journal of cancer · 2020Article
- The prediction of colorectal cancer using anthropometric measures: A Swedish population-based cohort study with 22 years of follow-up.United European gastroenterology journal · 2019Article
- Increasing colorectal cancer incidence in individuals aged < 50 years-a population-based study.International journal of colorectal disease · 2019Article
- Clinical Significance of Gender and Body Mass Index in Asian Patients with Colorectal Cancer.Journal of Cancer · 2019Article
- Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles.BMC cancer · 2018Article
- [Gender-specific differences of the early postoperative and oncosurgical long-term outcome in rectal cancer-data obtained in a prospective multicenter observational study].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Observational
- Factors influencing the number of retrieved lymph nodes after colorectal resection: a retrospective study from a single institute.International journal of clinical and experimental pathology · 2018Article
- A Prospective Investigation of Body Size, Body Fat Composition and Colorectal Cancer Risk in the UK Biobank.Scientific reports · 2017Article
- Obesity and Energy Balance in GI Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundIt remains unclear whether the increased risk of colorectal cancer (CRC) associated with obesity differs by gender, distribution of fat, tumour location and clinical (TNM) stage. The primary aim of this study was to examine these associations in 584 incident colorectal cancer cases from a Swedish prospective population-based cohort including 28098 men and women.
methodsSeven anthropometric factors; height, weight, bodyfat percentage, hip circumference, waist circumference, BMI and waist-hip ratio (WHR) were categorized into quartiles of baseline anthropometric measurements. Relative risks of CRC, total risk as well as risk of different TNM stages, and risk of tumours located to the colon or rectum, were calculated for all cases, women and men, respectively, using multivariate Cox regression models.
resultsObesity, as defined by all anthropometric variables, was significantly associated with an overall increased risk of CRC in both women and men. While none of the anthropometric measures was significantly associated with risk of tumour (T)-stage 1 and 2 tumours, all anthropometric variables were significantly associated with an increased risk of T-stage 3 and 4, in particular in men. In men, increasing quartiles of weight, hip, waist, BMI and WHR were significantly associated with an increased risk of lymph node positive (N1 and N2) disease, and risk of both non-metastatic (M0) and metastatic (M1) disease. In women, there were no or weak associations between obesity and risk of node-positive disease, but statistically significant associations between increased weight, bodyfat percentage, hip, BMI and M0 disease. Interestingly, there was an increased risk of colon but not rectal cancer in men, and rectal but not colon cancer in women, by increased measures of weight, hip-, waist circumference and bodyfat percentage.
conclusionsThis study is the first to show a relationship between obesity, measured as several different anthropometric factors, and an increased risk of colorectal cancer of more advanced clinical stage, in particular in men. These findings suggest that risk of CRC differs according to the method of characterising obesity, and also according to gender, location, and tumour stage.
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Registered trials
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