ArticleScientific reports2012
The computational influence of neurogenesis in the processing of spatial information in the dentate gyrus.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Computational Modeling of Adult Neurogenesis.Cold Spring Harbor perspectives in biology · 2016Review
- Dynamic role of adult-born dentate granule cells in memory processing.Current opinion in neurobiology · 2015Review
- Neurogenesis paradoxically decreases both pattern separation and memory interference.Frontiers in systems neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was designed to analyze the effect of hippocampal neurogenesis on the spatial maps of granule cells. Accordingly, we developed and improved an artificial neural network that was originally proposed by Aimone. Many biological processes were included in this revised model to improve the biological relevance of the results. We proposed a novel learning-testing protocol to analyze the activation of encoding place cells across contexts and over time in the dentate gyrus. We observed that, regardless of the presence of neurogenesis, the quantity and morphology of the place fields were represented in the same manner by granule cells. Additionally, we observed that neurogenesis was an effective mechanism for reducing the degree of rate remapping that occurred in the place fields of the granule cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.