ArticleInternational journal of clinical and experimental pathology2012
Pathogenic characterization of a cervical lymph node derived from a patient with Kawasaki disease.
Article in International journal of clinical and experimental pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Clinical characteristics of cervical lymphadenopathy in Kawasaki disease and the generation of related cervical complications: a retrospective cohort study.European journal of medical research · 2025Article
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Streptococcal infection and autoimmune diseases.Frontiers in immunology · 2024Review
- Kawasaki disease with peritonsillar abscess as the first symptom: A case report.World journal of clinical cases · 2023Article
- Emerging evidence of microbial infection in causing systematic immune vasculitis in Kawasaki disease.Frontiers in microbiology · 2023Review
- Identification of Viral Signatures Using High-Throughput Sequencing on Blood of Patients With Kawasaki Disease.Frontiers in pediatrics · 2019Article
- Article
- Identifying genetic hypomethylation and upregulation of Toll-like receptors in Kawasaki disease.Oncotarget · 2017Article
- Comprehensive pathogen detection associated with four recurrent episodes of Kawasaki disease in a patient during a single year using next-generation sequencing.JMM case reports · 2016Article
- Characterization of the gut microbiota of Kawasaki disease patients by metagenomic analysis.Frontiers in microbiology · 2015Article
- Erythema multiforme as first sign of incomplete Kawasaki disease.Italian journal of pediatrics · 2013Article
- Complete genes may pass from food to human blood.PloS one · 2013Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease (KD) is the most common cause of multisystem vasculitis in childhood. Although cervical lymphadenitis is one of the major symptoms in KD, lymph node biopsy is rarely performed, because KD is usually diagnosed by clinical symptoms. A cervical lymph node biopsy was taken from a girl aged 1 year and 8 months who had suspected lymphoma, but she was diagnosed with KD after the biopsy. The cervical lymph node specimen was analyzed with multivirus real-time PCR that can detect >160 viruses, and unbiased direct sequencing with a next-generation DNA sequencer to detect potential pathogens in the lymph node. Histologically, focal necrosis with inflammatory cell infiltration, including neutrophils and macrophages, was observed in the marginal zone of the cervical lymph node, which was compatible with the acute phase of KD. Multivirus real-time PCR detected a low copy number of torque teno virus in the sample. Comprehensive direct sequencing of the cervical lymph node biopsy sample sequenced more than 8 million and 3 million reads from DNA and RNA samples, respectively. Bacterial genomes were detected in 0.03% and 1.79% of all reads in DNA and RNA samples, respectively. Although many reads corresponded to genomes of bacterial environmental microorganisms, Streptococcus spp. genome was detected in both DNA (77 reads) and RNA (2,925 reads) samples. Further studies are required to reveal any association of microbial or viral infection with the pathogenesis of KD.
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Identifiers
23071864PMC3466979W63864481What OpenQuestion holds
Registered trials
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