ArticlePloS one2012
Long-lasting effects of sepsis on circadian rhythms in the mouse.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Systemic inflammation and microglial activation: systematic review of animal experiments.Journal of neuroinflammation · 2015Pooled it
- The interplay between circadian rhythm components and apoptosis in health and disease.Human cell · 2026Review
- Bidirectional Interaction of Sepsis and Sleep Disorders: The Underlying Mechanisms and Clinical Implications.Nature and science of sleep · 2024Review
- Many faces of sleep regulation: beyond the time of day and prior wake time.The FEBS journal · 2023Review
- Chronobiology of Parkinson's disease: Past, present and future.The European journal of neuroscience · 2023Review
- Article
- Chronobiology of limbic seizures: Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy.Neuroscience and biobehavioral reviews · 2019Review
- A Personalized Signature and Chronotherapy-Based Platform for Improving the Efficacy of Sepsis Treatment.Frontiers in physiology · 2019Review
- Clinical chronobiology: a timely consideration in critical care medicine.Critical care (London, England) · 2018Review
- Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Frontiers in neurology · 2018Article
- Neural Damage in ExperimentalFrontiers in neuroanatomy · 2018Article
- How does healthy aging impact on the circadian clock?Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism.Scientific reports · 2017Article
- Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.Neurobiology of aging · 2016Article
- Does prior sepsis alter subsequent circadian and sickness behaviour response to lipopolysaccharide treatment in mice?Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.Neurobiology of aging · 2015Article
- Microglia inflammatory responses are controlled by an intrinsic circadian clock.Brain, behavior, and immunity · 2015Article
- Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain.PloS one · 2015Article
- Article
- A Chemical Engineer's Perspective on Health and Disease.Computers & chemical engineering · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Daily patterns of activity and physiology are termed circadian rhythms and are driven primarily by an endogenous biological timekeeping system, with the master clock located in the suprachiasmatic nucleus. Previous studies have indicated reciprocal relationships between the circadian and the immune systems, although to date there have been only limited explorations of the long-term modulation of the circadian system by immune challenge, and it is to this question that we addressed ourselves in the current study. Sepsis was induced by peripheral treatment with lipopolysaccharide (5 mg/kg) and circadian rhythms were monitored following recovery. The basic parameters of circadian rhythmicity (free-running period and rhythm amplitude, entrainment to a light/dark cycle) were unaltered in post-septic animals compared to controls. Animals previously treated with LPS showed accelerated re-entrainment to a 6 hour advance of the light/dark cycle, and showed larger phase advances induced by photic stimulation in the late night phase. Photic induction of the immediate early genes c-FOS, EGR-1 and ARC was not altered, and neither was phase-shifting in response to treatment with the 5-HT-1a/7 agonist 8-OH-DPAT. Circadian expression of the clock gene product PER2 was altered in the suprachiasmatic nucleus of post-septic animals, and PER1 and PER2 expression patterns were altered also in the hippocampus. Examination of the suprachiasmatic nucleus 3 months after treatment with LPS showed persistent upregulation of the microglial markers CD-11b and F4/80, but no changes in the expression of various neuropeptides, cytokines, and intracellular signallers. The effects of sepsis on circadian rhythms does not seem to be driven by cell death, as 24 hours after LPS treatment there was no evidence for apoptosis in the suprachiasmatic nucleus as judged by TUNEL and cleaved-caspase 3 staining. Overall these data provide novel insight into how septic shock exerts chronic effects on the mammalian circadian system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.