ArticlePloS one2012
Potential drug-drug interactions in prescriptions to patients over 45 years of age in primary care, southern Brazil.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Prevalence of Drug-Drug Interactions in Older Community-Dwelling Individuals: A Systematic Review and Meta-analysis.Drugs & aging · 2023 · on this mapPooled it
- Drug-drug interaction software in clinical practice: a systematic review.European journal of clinical pharmacology · 2015Pooled it
- Prevalence, predictors, and clinical relevance of drug-drug interactions in outpatient prescribing: A national cross-sectional study.PloS one · 2026Article
- Use of herbal medicinal products among patients in primary health care in a Brazilian southeastern city: evidence from the Prover project.Einstein (Sao Paulo, Brazil) · 2024Article
- Determination of potential drug-drug interactions in prescription orders dispensed in a community pharmacy setting using MicromedexInternational journal of clinical pharmacy · 2022Observational
- Drug-drug interactions among hospitalized elderly in patients at medical wards of Northwest Ethiopia's Comprehensive Specialized Hospitals: A multicenter observational study.SAGE open medicine · 2022Article
- Potential drug-drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan.Journal of pharmaceutical health care and sciences · 2021Article
- Survey on Polypharmacy and Drug-Drug Interactions Among Elderly People with Cardiovascular Diseases at Yekatit 12 Hospital, Addis Ababa, Ethiopia.Integrated pharmacy research & practice · 2020Article
- Prevalence and predictors of potential drug-drug interactions in patients of internal medicine wards of a tertiary care hospital in India.European journal of hospital pharmacy : science and practice · 2018Article
- Detection of drug-drug interactions through data mining studies using clinical sources, scientific literature and social media.Briefings in bioinformatics · 2018Review
- Prevalence of drug-drug interactions in geriatric patients at an ambulatory care pharmacy in a tertiary care teaching hospital.BMC research notes · 2018Article
- Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital.Journal of aging research · 2018Article
- Evaluation of Faculty and Non-faculty Physicians' Medication Errors in Outpatients' Prescriptions in Shiraz, Iran.Iranian journal of pharmaceutical research : IJPR · 2018Article
- Potential drug-drug interactions in inpatients treated at the Internal Medicine ward of Tikur Anbessa Specialized Hospital.Drug, healthcare and patient safety · 2017Article
- Potentially severe drug-drug interactions among older people and associations in assisted living facilities in Finland: a cross-sectional study.Scandinavian journal of primary health care · 2016Article
- Inappropriate Medication Use Among Underserved Elderly African Americans.Journal of aging and health · 2016Article
- Prevalence of polypharmacy and risk of potential drug-drug interactions among hospitalized patients with emphasis on the pharmacokinetics.Science progressArticle
- Incidence rate and pattern of clinically relevant potential drug-drug interactions in a large outpatient population of a developing country.Research in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew cross-sectional studies involving adults and elderly patients with major DDIs have been conducted in the primary care setting. The study aimed to investigate the prevalence of potential drug-drug interactions (DDIs) in patients treated in primary care. METHODOLOGY/PRINCIPAL
findingsA cross-sectional study involving patients aged 45 years or older was conducted at 25 Basic Health Units in the city of Maringá (southern Brazil) from May to December 2010. The data were collected from prescriptions at the pharmacy of the health unit at the time of the delivery of medication to the patient. After delivery, the researcher checked the electronic medical records of the patient. A total of 827 patients were investigated (mean age: 64.1; mean number of medications: 4.4). DDIs were identified in the Micromedex® database. The prevalence of potential DDIs and major DDIs was 63.0% and 12.1%, respectively. In both the univariate and multivariate analyses, the number of drugs prescribed was significantly associated with potential DDIs, with an increasing risk from three to five drugs (OR = 4.74; 95% CI: 2.90-7.73) to six or more drugs (OR = 23.03; 95% CI: 10.42-50.91). Forty drugs accounted for 122 pairs of major DDIs, the most frequent of which involved simvastatin (23.8%), captopril/enalapril (16.4%) and fluoxetine (16.4%). CONCLUSIONS/SIGNIFICANCE: This is the first large-scale study on primary care carried out in Latin America. Based on the findings, the estimated prevalence of potential DDIs was high, whereas clinically significant DDIs occurred in a smaller proportion. Exposing patients to a greater number of prescription drugs, especially three or more, proved to be a significant predictor of DDIs. Prescribers should be more aware of potential DDIs. Future studies should assess potential DDIs in primary care over a longer period of time.
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