ArticlePloS one2012
Risk of cardiovascular disease in a traditional African population with a high infectious load: a population-based study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02002143 (Group Medical Visits), which is not on this map. Cited by 31 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Group Medical Visits (GMVs) in Primary Care: An RCT of Group-Based Versus Individual Appointments to Reduce HbA1c in Older People
Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prevalence of hypertension in Ghanaian society: a systematic review, meta-analysis, and GRADE assessment.Systematic reviews · 2021Pooled it
- Prevalence, awareness and control of hypertension in Ghana: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Determinants of systemic hypertension in older adults in Africa: a systematic review.BMC cardiovascular disorders · 2019Pooled it
- Pooled it
- Estimating the prevalence and awareness rates of hypertension in Africa: a systematic analysis.PloS one · 2014Pooled it
- Comparison of age-related inflammation and oxidative stress in two lemur species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Obesity phenotypes and dyslipidemia in adults from four African countries: An H3Africa AWI-Gen study.PloS one · 2025Article
- Lower Socioeconomic Status Predicts Increased Proinflammatory Signaling in Late Pregnancy: Evidence From a Filipino Cohort.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Three common assumptions about inflammation, aging, and health that are probably wrong.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The rise and fall of tobacco smoking and associated rise and fall of coronary atherosclerosis the lethal role of tobacco.Frontiers in cardiovascular medicine · 2023Review
- Infection and food combine to cause atherosclerotic coronary heart disease - Review and hypothesis.International journal of cardiology. Heart & vasculature · 2021Review
- Genome-wide DNA methylation analysis on C-reactive protein among Ghanaians suggests molecular links to the emerging risk of cardiovascular diseases.NPJ genomic medicine · 2021Article
- Malaria link of hypertension: a hidden syndicate of angiotensin II, bradykinin and sphingosine 1-phosphate.Human cell · 2021Review
- [Multiparametric biochemical analysis revealing an increase of homocysteinemia and NT-proBNP in hypertensive patients living in Bamako (Mali)].The Pan African medical journal · 2020Article
- Epidemiological links between malaria parasitaemia and hypertension: findings from a population-based survey in rural Côte d'Ivoire.Journal of hypertension · 2019Article
- The effect of disease burden on the speed of aging: an analysis of the Sardinian mortality transition.Genus · 2018Article
- Côte d'Ivoire Dual Burden of Disease (CoDuBu): Study Protocol to Investigate the Co-occurrence of Chronic Infections and Noncommunicable Diseases in Rural Settings of Epidemiological Transition.JMIR research protocols · 2017Article
- Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study.Lancet (London, England) · 2017Article
- Monocyte Chemoattractant Protein-1 and Large Artery Structure and Function in Young Individuals: The African-PREDICT Study.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo test the inflammatory origin of cardiovascular disease, as opposed to its origin in western lifestyle. Population-based assessment of the prevalences of cardiovascular risk factors and cardiovascular disease in an inflammation-prone African population, including electrocardiography and ankle-arm index measurement. Comparison with known prevalences in American and European societies. METHODOLOGY/PRINCIPAL
findingsTraditional population in rural Ghana, characterised by adverse environmental conditions and a high infectious load. Population-based sample of 924 individuals aged 50 years and older. Median values for cardiovascular risk factors, including waist circumference, BMI, blood pressure, and markers of glucose and lipid metabolism and inflammation. Prevalence of myocardial infarction detected by electrocardiography and prevalence of peripheral arterial disease detected by ankle-arm index. When compared to western societies, we found the Ghanaians to have more proinflammatory profiles and less cardiovascular risk factors, including obesity, dysglycaemia, dyslipidaemia, and hypertension. Prevalences of cardiovascular disease were also lower. Definite myocardial infarction was present in 1.2% (95%CI: 0.6 to 2.4%). Peripheral arterial disease was present in 2.8% (95%CI: 1.9 to 4.1%). CONCLUSIONS/SIGNIFICANCE: Taken together, our data indicate that for the pathogenesis of cardiovascular disease inflammatory processes alone do not suffice and additional factors, probably lifestyle-related, are mandatory.
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