ArticlePloS one2012
The association between enterovirus 71 infections and meteorological parameters in Taiwan.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- The effect of daily mean temperature on hand, foot and mouth disease and the source of regional heterogeneity in Chongqing, China, 2010-2019.Environmental health and preventive medicine · 2022Pooled it
- The Epidemiology of Hand, Foot and Mouth Disease in Asia: A Systematic Review and Analysis.The Pediatric infectious disease journal · 2016Pooled it
- Pooled it
- Lag effects of meteorological factors on the risk of daily outpatient visits for herpangina in Guangzhou (2014-2023).Frontiers in pediatrics · 2026Article
- Article
- Insight into the Life Cycle of Enterovirus-A71.Viruses · 2025Review
- Structural time series modelling for weekly forecasting of enterovirus outpatient, inpatient, and emergency department visits.PloS one · 2025Article
- Changing Epidemiology of Hand, Foot, and Mouth Disease Causative Agents and Contributing Factors.The American journal of tropical medicine and hygiene · 2024Review
- Epidemiology of childhood enterovirus infections in Hangzhou, China, 2019-2023.Virology journal · 2024Article
- Article
- Non-linear association between daily mean temperature and children's hand foot and mouth disease in Chongqing, China.Scientific reports · 2023Article
- Periodic Characteristics of Hepatitis Virus Infections From 2013 to 2020 and Their Association With Meteorological Factors in Guangdong, China: Surveillance Study.JMIR public health and surveillance · 2023Article
- Study of the influence of meteorological factors on HFMD and prediction based on the LSTM algorithm in Fuzhou, China.BMC infectious diseases · 2023Article
- Molecular Epidemiology of Enterovirus A71 in Surveillance of Acute Flaccid Paralysis Cases in Senegal, 2013-2020.Vaccines · 2022Article
- Effects of temperature and PMEnvironmental science and pollution research international · 2022Article
- Seasonality and Meteorological Factors Associated With Different Hand, Foot, and Mouth Disease: Serotype-Specific Analysis From 2010 to 2018 in Zhejiang Province, China.Frontiers in microbiology · 2022Article
- The incidence of mumps in Taiwan and its association with the meteorological parameters: An observational study.Medicine · 2021Observational
- Comparison of ARIMA and LSTM in Forecasting the Incidence of HFMD Combined and Uncombined with Exogenous Meteorological Variables in Ningbo, China.International journal of environmental research and public health · 2021Article
- Effect of climate factors on the incidence of hand, foot, and mouth disease in Malaysia: A generalized additive mixed model.Infectious Disease Modelling · 2021Article
- Analysis of the Complete Genomes of Enterovirus 71 Subtypes in China.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnterovirus 71 (EV71) infections are a significant cause of neurological disorder and death in children worldwide. Seasonal variations in EV71 infections have been recognized, but the mechanisms responsible for this phenomenon remain unknown. The purpose of this study was to examine the relationship between meteorological parameters and EV71 infection. METHODS AND
findingsWe analyzed the number of EV71 infections and daily climate data collected in Taiwan between 1998 and 2008 and used Poisson regression analysis and case-crossover methodology to evaluate the association between weather variability and the incidence of EV71 infection. A total of 1,914 EV71-infected patients were reported between 1998 and 2008. The incidence of EV71 infections reflected significant summertime seasonality (for oscillation, p<0.001). The incidence of EV71 infections began to rise at temperatures above 13°C (r(2) = 0.76, p<0.001); at temperatures higher than approximately 26°C (r(2) = 0.94, p<0.05), the incidence began to decline, producing an inverted V-shaped relationship. The increase in the incidence with increasing relative humidity was positive and linear (r(2) = 0.68, p<0.05). EV71 infection was most highly correlated with temperature and relative humidity in the period that likely preceded the infection.
conclusionOur study provides quantitative evidence that the rate of EV71 infection increased significantly with increasing mean temperature and relative humidity in Taiwan.
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