ArticlePloS one2012
Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV- Tuberculosis Immune Reconstitution Inflammatory Syndrome.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- IFN-γ and IL-10 Immunosensor with Vertically Aligned Carbon Nanotube Interdigitated Electrodes toward Pen-Side Cattle Paratuberculosis Monitoring.Global challenges (Hoboken, NJ) · 2024Article
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- Sensitivity and specificity of the mean corpuscular volume and CD4/CD8 ratio in discriminating between rifampicin resistant and rifampicin sensitive tuberculosis.Journal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- Baseline IFN-γ and IL-10 expression in PBMCs could predict response to PD-1 checkpoint inhibitors in advanced melanoma patients.Scientific reports · 2020Article
- Immunometabolism during Mycobacterium tuberculosis Infection.Trends in microbiology · 2020Review
- LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1.Oncogenesis · 2020Article
- 7-oxo-DHEA enhances impaired M. tuberculosis-specific T cell responses during HIV-TB coinfection.Journal of biomedical science · 2020Article
- FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune Response.Frontiers in immunology · 2019Article
- TB-IRIS: Proteomic analysis of in vitro PBMC responses to Mycobacterium tuberculosis and response modulation by dexamethasone.Experimental and molecular pathology · 2017Article
- HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome.Seminars in immunopathology · 2016Review
- Circulating Interferon-Gamma Levels Are Associated with Low Body Weight in Newly Diagnosed Kenyan Non-Substance Using Tuberculosis Individuals.Interdisciplinary perspectives on infectious diseases · 2016Article
- Tuberculosis and HIV Coinfection.Cold Spring Harbor perspectives in medicine · 2015Review
- Immune reconstitution disorders in patients with HIV infection: from pathogenesis to prevention and treatment.Current HIV/AIDS reports · 2014Article
- Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis.The Lancet. Respiratory medicine · 2014Review
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
We have described a clinical relationship between HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) and anti-tubercular drug resistance. Here we studied the immune response of TB-IRIS patients from whom a drug-resistant (n = 11) or drug-susceptible (n = 25) Mycobacterium tuberculosis (MTB) strain was isolated after presenting with TB-IRIS. ELISpot analysis and multiplex cytokine analysis of the supernatant collected from peripheral blood mononuclear cells stimulated overnight with the heat-killed H37Rv MTB laboratory strain was used. Although there was no statistical difference in IFN-gamma ELISpot responses between the two groups, the results point towards higher bacterial load in the drug-resistant patients, possibly due to failed therapy. The ratio between secreted IFN-gamma/IL-10 and IL-2/IL-10 was significantly lower in TB-IRIS patients in whom the cause of TB was a drug-resistant strain compared to those with a fully sensitive strain (p = 0.02). Since host immune responses are dependent on the bacterial load, we hypothesise that the impaired cytokine balance is likely to be caused by the poorly controlled bacterial growth in these patients.
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