Evidence map›Paper›PMID 23071550›Full record

ArticlePloS one2012

Validation of an automated cough detection algorithm for tracking recovery of pulmonary tuberculosis patients.

Sandra Larson, Germán Comina, Robert H Gilman, Brian H Tracey, Marjory Bravard, José W López

Abstract readValidation Study
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Making cough count in tuberculosis care.Communications medicine · 2022
    Review
  13. Article
  14. The present and future of cough counting tools.Journal of thoracic disease · 2020
    Review
  15. Article
  16. Article
  17. Estimation of Cough Peak Flow Using Cough Sounds.Sensors (Basel, Switzerland) · 2018
    Article
  18. Article
  19. Dynamics of Cough Frequency in Adults Undergoing Treatment for Pulmonary Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandra LarsonCollege of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America.
Germán Comina
Robert H Gilman
Brian H Tracey
Marjory Bravard
José W López

Funding

Infectious Diseases Training Program in PeruD43TW006581 · FIC · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2003 to 2012
$2.4M
Cough - A Rapid Indicator of Response to Therapy in Pulmonary TuberculosisR21AI094143 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2012 to 2013
$388k
FIC NIH HHS 5D43TW006581FIC NIH HHS D43 TW006581Medical Research Council MR/K007467/1NIAID NIH HHS R21 AI094143NIAID NIH HHS R21AI094143
6 · The paper itself

Abstract

backgroundA laboratory-free test for assessing recovery from pulmonary tuberculosis (TB) would be extremely beneficial in regions of the world where laboratory facilities are lacking. Our hypothesis is that analysis of cough sound recordings may provide such a test. In the current paper, we present validation of a cough analysis tool. METHODOLOGY/PRINCIPAL

findingsCough data was collected from a cohort of TB patients in Lima, Peru and 25.5 hours of recordings were manually annotated by clinical staff. Analysis software was developed and validated by comparison to manual scoring. Because many patients cough in bursts, coughing was characterized in terms of cough epochs. Our software correctly detects 75.5% of cough episodes with a specificity of 99.6% (comparable to past results using the same definition) and a median false positive rate of 4 false positives/hour, due to the noisy, real-world nature of our dataset. We then manually review detected coughs to eliminate false positives, in effect using the algorithm as a pre-screening tool that reduces reviewing time to roughly 5% of the recording length. This cough analysis approach provides a foundation to support larger-scale studies of coughing rates over time for TB patients undergoing treatment.

Indexed as

AlgorithmsAutomationCohort StudiesCoughHumansPeruTuberculosis, Pulmonary

Identifiers

PMID23071550
PMCPMC3468608

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.