ArticlePloS one2012
Effect of maternal probiotic intervention on HPA axis, immunity and gut microbiota in a rat model of irritable bowel syndrome.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 95 citations in OpenAlex.
- Dairy Propionibacteria: Probiotic Properties and Their Molecular Bases.Biomolecules · 2025Review
- Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress.Neurobiology of stress · 2024Article
- A gut (microbiome) feeling about addiction: Interactions with stress and social systems.Neurobiology of stress · 2024Review
- Butterflies in the gut: the interplay between intestinal microbiota and stress.Journal of biomedical science · 2023Review
- Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways.Neurochemical research · 2022Article
- Comparison Between Different Delivery Vehicles for the Probiotic Bifidobacterium animalis subsp. lactis HN019 on Experimental Periodontitis in Rats.Probiotics and antimicrobial proteins · 2022Article
- The Effects of Synbiotics Administration on Stress-Related Parameters in Thai Subjects-A Preliminary Study.Foods (Basel, Switzerland) · 2022Article
- Psychobiotic Therapy: Method to Reinforce the Immune System.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Review
- The Potential Impact of Selected Bacterial Strains on the Stress Response.Healthcare (Basel, Switzerland) · 2021Review
- Supplementation of Diets With Bovine Colostrum Influences Immune and Gut Function in Kittens.Frontiers in veterinary science · 2021Article
- Gut Microbiota Regulate Astrocytic Functions in the Brain: Possible Therapeutic Consequences.Current neuropharmacology · 2021Article
- Alleviation of Anxiety/Depressive-Like Behaviors and Improvement of Cognitive Functions byThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- The Volatile Oil ofDrug design, development and therapy · 2021Article
- Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression.Gut microbes · 2020Article
- Neuropeptides in gut-brain axis and their influence on host immunity and stress.Computational and structural biotechnology journal · 2020Review
- The microbiota-gut-brain axis: An emerging role for the epigenome.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Making Sense of … the Microbiome in Psychiatry.The international journal of neuropsychopharmacology · 2019Review
- Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation.Frontiers in immunology · 2019Review
- Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus.Translational psychiatry · 2018Article
- Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether maternal probiotic intervention influences the alterations in the brain-immune-gut axis induced by neonatal maternal separation (MS) and/or restraint stress in adulthood (AS) in Wistar rats.
designDams had free access to drinking water supplemented with Bifidobacterium animalis subsp lactis BB-12® (3 × 10(9) CFU/mL) and Propionibacterium jensenii 702 (8.0 × 10(8) CFU/mL) from 10 days before conception until postnatal day (PND) 22 (weaning day), or to control ad lib water. Offspring were subjected to MS from PND 2 to 14 or left undisturbed. From PND 83 to 85, animals underwent 30 min/day AS, or were left undisturbed as controls. On PND 24 and 86, blood samples were collected for corticosterone, ACTH and IgA measurement. Colonic contents were analysed for the composition of microflora and luminal IgA levels.
resultsExposure to MS significantly increased ACTH levels and neonatal fecal counts of aerobic and anaerobic bacteria, E. coli, enterococci and clostridia, but reduced plasma IgA levels compared with non-MS animals. Animals exposed to AS exhibited significantly increased ACTH and corticosterone levels, decreased aerobic bacteria and bifidobacteria, and increased Bacteroides and E. coli counts compared to non-AS animals. MS coupled with AS induced significantly decreased anaerobes and clostridia compared with the non-stress adult controls. Maternal probiotic intervention significantly increased neonatal corticosterone levels which persisted until at least week 12 in females only, and also resulted in elevated adult ACTH levels and altered neonatal microflora comparable to that of MS. However, it improved plasma IgA responses, increased enterococci and clostridia in MS adults, increased luminal IgA levels, and restored anaerobes, bifidobacteria and E. coli to normal in adults.
conclusionMaternal probiotic intervention induced activation of neonatal stress pathways and an imbalance in gut microflora. Importantly however, it improved the immune environment of stressed animals and protected, in part, against stress-induced disturbances in adult gut microflora.
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