ArticlePloS one2012
Early life stress differentially modulates distinct forms of brain plasticity in young and adult mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Animal Model of Autism Induced by Valproic Acid Combined with Maternal Deprivation: Sex-Specific Effects on Inflammation and Oxidative Stress.Molecular neurobiology · 2025Article
- Early-life stress differentially affects CA3 synaptic inputs converging on apical and basal dendrites of CA1 pyramidal neurons.Frontiers in neural circuits · 2025Article
- Sinisan ameliorates early-life stress-induced depressive-like behaviors by repairing DRN synaptic damage through CaSR.Frontiers in pharmacology · 2025Article
- Coffee polyphenols ameliorate early-life stress-induced cognitive deficits in male mice.Neurobiology of stress · 2024Article
- Influence of early-life stress on hippocampal synaptic and network properties.Frontiers in neural circuits · 2024Review
- Neonatal Maternal Separation Induces Sexual Dimorphism in Brain Development: The Influence on Amino Acid Levels and Cognitive Disorders.Biomolecules · 2023Article
- Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.Translational psychiatry · 2023Article
- Neonatal Maternal Separation Alters Gelatinase Activity in Mouse Ovarian Preantral Follicles.Cell journal · 2021Article
- Negative relationship between brain αExperimental brain research · 2020Article
- A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress.Neurobiology of stress · 2018Review
- Effects of Early-Life Stress on Social and Anxiety-Like Behaviors in Adult Mice: Sex-Specific Effects.Behavioural neurology · 2018Article
- Early life stress-induced alterations in rat brain structures measured with high resolution MRI.PloS one · 2017Article
- Effects of early life stress on depression, cognitive performance and brain morphology.Psychological medicine · 2017Article
- Maternal Forced Swimming Reduces Cell Proliferation in the Postnatal Dentate Gyrus of Mouse Offspring.Frontiers in neuroscience · 2016Article
- Early-Life Social Isolation Impairs the Gonadotropin-Inhibitory Hormone Neuronal Activity and Serotonergic System in Male Rats.Frontiers in endocrinology · 2015Article
- Sex-dependent effects of an early life treatment in rats that increases maternal care: vulnerability or resilience?Frontiers in behavioral neuroscience · 2014Article
- Brain-derived neurotrophic factor inhibits glucose intolerance after cerebral ischemia.Neural regeneration research · 2013Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly life trauma is an important risk factor for many psychiatric and somatic disorders in adulthood. As a growing body of evidence suggests that brain plasticity is disturbed in affective disorders, we examined the short-term and remote effects of early life stress on different forms of brain plasticity. METHODOLOGY/PRINCIPAL
findingsMice were subjected to early deprivation by individually separating pups from their dam in the first two weeks after birth. Distinct forms of brain plasticity were assessed in the hippocampus by longitudinal MR volumetry, immunohistochemistry of neurogenesis, and whole-cell patch-clamp measurements of synaptic plasticity. Depression-related behavior was assessed by the forced swimming test in adult animals. Neuropeptides and their receptors were determined by real-time PCR and immunoassay. Early maternal deprivation caused a loss of hippocampal volume, which returned to normal in adulthood. Adult neurogenesis was unaffected by early life stress. Long-term synaptic potentiation, however, was normal immediately after the end of the stress protocol but was impaired in adult animals. In the forced swimming test, adult animals that had been subjected to early life stress showed increased immobility time. Levels of substance P were increased both in young and adult animals after early deprivation.
conclusionHippocampal volume was affected by early life stress but recovered in adulthood which corresponded to normal adult neurogenesis. Synaptic plasticity, however, exhibited a delayed impairment. The modulation of synaptic plasticity by early life stress might contribute to affective dysfunction in adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.