ArticlePediatrics2012
Genotype prediction of adult type 2 diabetes from adolescence in a multiracial population.
Article in Pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bogalusa Heart Study
Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis.Journal of epidemiology · 2018Pooled it
- Predicting risk of type 2 diabetes mellitus with genetic risk models on the basis of established genome-wide association markers: a systematic review.American journal of epidemiology · 2013Pooled it
- Trial
- Genomic Innovation in Early Life Cardiovascular Disease Prevention and Treatment.Circulation research · 2023Review
- Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.Genome medicine · 2022Article
- Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents.Human molecular genetics · 2022Article
- Genome-wide association study identifying novel variant for fasting insulin and allelic heterogeneity in known glycemic loci in Chilean adolescents: The Santiago Longitudinal Study.Pediatric obesity · 2021Article
- Protein Glycosylation in Diabetes.Advances in experimental medicine and biology · 2021Article
- Agreement between Type 2 Diabetes Risk Scales in a Caucasian Population: A Systematic Review and Report.Journal of clinical medicine · 2020Article
- "H" for Heterogeneity in the Algorithm for Type 2 Diabetes Management.Current diabetes reports · 2020Review
- Article
- A Decade of Genetic and Metabolomic Contributions to Type 2 Diabetes Risk Prediction.Current diabetes reports · 2017Review
- Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study.Diabetologia · 2017Article
- Association between impaired fasting glycaemia in pediatric obesity and type 2 diabetes in young adulthood.Nutrition & diabetes · 2016Article
- Improved prediction of complex diseases by common genetic markers: state of the art and further perspectives.Human genetics · 2016Review
- Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.Circulation. Cardiovascular genetics · 2015Article
- A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents.Journal of diabetes research · 2015Article
- Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes.The application of clinical genetics · 2015Review
- Article
- Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes.Diabetes care · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundUnderstanding the risk for type 2 diabetes (T2D) early in the life course is important for prevention. Whether genetic information improves prediction models for diabetes from adolescence into adulthood is unknown.
methodsWith the use of data from 1030 participants in the Bogalusa Heart Study aged 12 to 18 followed into middle adulthood, we built Cox models for incident T2D with risk factors assessed in adolescence (demographics, family history, physical examination, and routine biomarkers). Models with and without a 38 single-nucleotide polymorphism diabetes genotype score were compared by C statistics and continuous net reclassification improvement indices.
resultsParticipant mean (± SD) age at baseline was 14.4 ± 1.6 years, and 32% were black. Ninety (8.7%) participants developed T2D over a mean 26.9 ± 5.0 years of follow-up. Genotype score significantly predicted T2D in all models. Hazard ratios ranged from 1.09 per risk allele (95% confidence interval 1.03-1.15) in the basic demographic model to 1.06 (95% confidence interval 1.00-1.13) in the full model. The addition of genotype score did not improve the discrimination of the full clinical model (C statistic 0.756 without and 0.760 with genotype score). In the full model, genotype score had weak improvement in reclassification (net reclassification improvement index 0.261).
conclusionsAlthough a genotype score assessed among white and black adolescents is significantly associated with T2D in adulthood, it does not improve prediction over clinical risk factors. Genetic screening for T2D in its current state is not a useful addition to adolescents' clinical care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.