ArticleThe Journal of cell biology2012
miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 89 citations in OpenAlex.
- Identification of Long Noncoding RNA by In Situ Hybridization Approaches.Methods in molecular biology (Clifton, N.J.) · 2026Article
- MicroRNAs, endometrial receptivity and molecular pathways.Reproductive biology and endocrinology : RB&E · 2024Review
- Biomarkers for Oral Squamous Cell Carcinoma (miR-24, miR-200, and miR-34): Screening and Detection MicroRNA.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Direct Lineage Reprogramming for Induced Keratinocyte Stem Cells: A Potential Approach for Skin Repair.Stem cells translational medicine · 2023Review
- New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP.Discover oncology · 2021Article
- Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity.Reproductive biology and endocrinology : RB&E · 2021Article
- Impaired cell migration and structural defects in myeloid cells overexpressing miR-30b and miR-142-3p.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Article
- MicroRNA-200b/c-3p regulate epithelial plasticity and inhibit cutaneous wound healing by modulating TGF-β-mediated RAC1 signaling.Cell death & disease · 2020Article
- Post-transcriptional regulation of MRTF-A by miRNAs during myogenic differentiation of myoblasts.Nucleic acids research · 2020Article
- The Role of MicroRNAs in Epidermal Barrier.International journal of molecular sciences · 2020Review
- Identification of Long Noncoding RNA by In Situ Hybridization Approaches.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Article
- The role of noncoding RNAs in epithelial cancer.Cell death discovery · 2020Review
- β-catenin regulates effects of miR-24 on the viability and autophagy of glioma cells.Experimental and therapeutic medicine · 2019Article
- Overexpression of the Oral Mucosa-Specific microRNA-31 Promotes Skin Wound Closure.International journal of molecular sciences · 2019Article
- ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development.Oncogene · 2019Article
- MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis.Nature cell biology · 2019Article
- SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium.Stem cells (Dayton, Ohio) · 2019Article
- p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- MicroRNA-24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin-α3 and regulating inflammatory responses.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 5 countries.
Funding
Abstract
During keratinocyte differentiation and stratification, cells undergo extensive remodeling of their actin cytoskeleton, which is important to control cell mobility and to coordinate and stabilize adhesive structures necessary for functional epithelia. Limited knowledge exists on how the actin cytoskeleton is remodeled in epithelial stratification and whether cell shape is a key determinant to trigger terminal differentiation. In this paper, using human keratinocytes and mouse epidermis as models, we implicate miR-24 in actin adhesion dynamics and demonstrate that miR-24 directly controls actin cable formation and cell mobility. miR-24 overexpression in proliferating cells was sufficient to trigger keratinocyte differentiation both in vitro and in vivo and directly repressed cytoskeletal modulators (PAK4, Tks5, and ArhGAP19). Silencing of these targets recapitulated the effects of miR-24 overexpression. Our results uncover a new regulatory pathway involving a differentiation-promoting microribonucleic acid that regulates actin adhesion dynamics in human and mouse epidermis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.