Evidence map›Paper›PMID 23071076›Full record

SynthesisAnnals of neurology2012

Meta-analysis of early nonmotor features and risk factors for Parkinson disease.

Alastair J Noyce, Jonathan P Bestwick, Laura Silveira-Moriyama, Christopher H Hawkes, Gavin Giovannoni, Andrew J Lees, Anette Schrag

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 334 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
334citing papers in PubMed, 12 pooled it
28.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

334 citing papers in PubMed, 12 syntheses or guidelines pooled it, 760 citations in OpenAlex.

  1. Pooled it
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  3. Non-International journal of molecular sciences · 2024
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  7. Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis.Movement disorders : official journal of the Movement Disorder Society · 2021
    Pooled it
  8. Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression.Movement disorders : official journal of the Movement Disorder Society · 2021
    Pooled it
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274 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alastair J NoyceInstitute of Neurology, University College London, London, United Kingdom.
Jonathan P Bestwick
Laura Silveira-Moriyama
Christopher H Hawkes
Gavin Giovannoni
Andrew J Lees
Anette Schrag
Queen Mary University of London · GBUniversity College London · GBUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

Parkinson's UK F-1201Parkinson's UK K-1006
6 · The paper itself

Abstract

objectiveTo evaluate the association between diagnosis of Parkinson disease (PD) and risk factors or early symptoms amenable to population-based screening.

methodsA systematic review and meta-analysis of risk factors for PD.

resultsThe strongest associations with later diagnosis of PD were found for having a first-degree or any relative with PD (odds ratio [OR], 3.23; 95% confidence interval [CI], 2.65-3.93 and OR, 4.45; 95% CI, 3.39-5.83) or any relative with tremor (OR, 2.74; 95% CI, 2.10-3.57), constipation (relative risk [RR], 2.34; 95% CI, 1.55-3.53), or lack of smoking history (current vs never: RR, 0.44; 95% CI, 0.39-0.50), each at least doubling the risk of PD. Further positive significant associations were found for history of anxiety or depression, pesticide exposure, head injury, rural living, beta-blockers, farming occupation, and well-water drinking, and negative significant associations were found for coffee drinking, hypertension, nonsteroidal anti-inflammatory drugs, calcium channel blockers, and alcohol, but not for diabetes mellitus, cancer, oral contraceptive pill use, surgical menopause, hormone replacement therapy, statins, acetaminophen/paracetamol, aspirin, tea drinking, history of general anesthesia, or gastric ulcers. In the systematic review, additional associations included negative associations with raised serum urate, and single studies or studies with conflicting results.

interpretationThe strongest risk factors associated with later PD diagnosis are having a family history of PD or tremor, a history of constipation, and lack of smoking history. Further factors also but less strongly contribute to risk of PD diagnosis or, as some premotor symptoms, require further standardized studies to demonstrate the magnitude of risk associated with them.

Indexed as

Alcohol DrinkingAnti-Inflammatory Agents, Non-SteroidalCoffeeConfidence IntervalsFamily HealthFemaleHumansMaleMEDLINEOdds RatioParkinson DiseaseRisk FactorsSmokingTremorAnti-Inflammatory Agents, Non-SteroidalCoffee

Identifiers

PMID23071076
PMCPMC3556649
OpenAlexW1993790483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.