ArticleThe Journal of physiology2012
Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Sex-related differences in fine motor skills and muscle strength control during short-term fasting.Scientific reports · 2026Trial
- Nicotine supplementation enhances simulated game performance of archery athletes.Journal of the International Society of Sports Nutrition · 2021Trial
- BetaThe Journal of physiology · 2018Trial
- Chronic βThe Journal of physiology · 2018Trial
- High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men.European journal of applied physiology · 2014Trial
- Phosphorylation of RYR1 at SerScience signaling · 2025Article
- Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression.Nature communications · 2025Article
- Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel.International journal of molecular sciences · 2025Article
- E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Targeting skeletal muscle mitochondrial health in obesity.Clinical science (London, England : 1979) · 2022Review
- Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function ineLife · 2022Article
- A Comparative Perspective on Functionally-Related, Intracellular Calcium Channels: The Insect Ryanodine and Inositol 1,4,5-Trisphosphate Receptors.Biomolecules · 2021Review
- Regulation of muscle potassium: exercise performance, fatigue and health implications.European journal of applied physiology · 2021Review
- Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease: Pathogenesis and Therapeutic Targets.The American journal of pathology · 2021Review
- Article
- Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation.Nature communications · 2020Article
- Preclinical model systems of ryanodine receptor 1-related myopathies and malignant hyperthermia: a comprehensive scoping review of works published 1990-2019.Orphanet journal of rare diseases · 2020Article
- Crystal structure of diamondback moth ryanodine receptor Repeat34 domain reveals insect-specific phosphorylation sites.BMC biology · 2019Article
- Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms.Pflugers Archiv : European journal of physiology · 2019Article
- Epinephrine augments posttetanic potentiation in mouse skeletal muscle with and without myosin phosphorylation.Physiological reports · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Enhancement of contractile force (inotropy) occurs in skeletal muscle following neuroendocrine release of catecholamines and activation of muscle β-adrenergic receptors. Despite extensive study, the molecular mechanism underlying the inotropic response in skeletal muscle is not well understood. Here we show that phosphorylation of a single serine residue (S2844) in the sarcoplasmic reticulum (SR) Ca(2+) release channel/ryanodine receptor type 1 (RyR1) by protein kinase A (PKA) is critical for skeletal muscle inotropy. Treating fast twitch skeletal muscle from wild-type mice with the β-receptor agonist isoproterenol (isoprenaline) increased RyR1 PKA phosphorylation, twitch Ca(2+) and force generation. In contrast, the enhanced muscle Ca(2+), force and in vivo muscle strength responses following isoproterenol stimulation were abrogated in RyR1-S2844A mice in which the serine in the PKA site in RyR1 was replaced with alanine. These data suggest that the molecular mechanism underlying skeletal muscle inotropy requires enhanced SR Ca(2+) release due to PKA phosphorylation of S2844 in RyR1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.