ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Lymphocyte subsets in pediatric migraine.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Regulatory T cell levels in migraine: A systematic review and meta-analysis.The journal of headache and pain · 2026Pooled it
- Baseline immune biomarkers as predictors of MBSR(BC) treatment success in off-treatment breast cancer patients.Biological research for nursing · 2014Trial
- Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?The journal of headache and pain · 2025Article
- Common Clinical and Molecular Pathways between Migraine and Sarcoidosis.International journal of molecular sciences · 2023Review
- Toll-like receptors and their role in neuropathic pain and migraine.Molecular brain · 2022Review
- The role of the immune system and the biomarker CD3 + CD4 + CD45RA-CD62L- in the pathophysiology of migraine.Scientific reports · 2020Article
- Association between sequence variations of the Mediterranean fever gene and the risk of migraine: a case-control study.Neuropsychiatric disease and treatment · 2016Article
- Sex and the migraine brain.Neurobiology of disease · 2014Review
- Evaluation of immune parameters in chronic migraine with medication overuse.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- A Preliminary Meta-analysis of Regulatory T-cell Reduction in Patients With Migraine.Basic and clinical neuroscienceReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aseptic inflammation due to activated immune cells has been implicated in the pathomechanism of migraine. We measured the prevalence of regulatory T cells (Tregs), along with that of CD4(+)/CD8(+) lymphocytes and their Th1/Th2 commitment in pediatric migraine. Children and adolescents suffering from migraine without aura, migraine with aura and hemiplegic migraine ictally (n = 53, 27, and 20, respectively), also interictally (n = 33) were recruited and compared to 24 healthy children. Our results indicated comparable prevalence of Tregs, CD4(+) and Th1/Th2 committed cells. CD8(+) prevalence was lower, and CD4(+)/CD8(+) ratio was higher in ictal phase irrespective of the subtype of migraine. No association between CD8(+) prevalence and gender, body weight, disease onset and attack duration in migraine subtypes was found. CD8(+) prevalence was normal in patients in interictal phase. These results suggest the absence of major systemic alteration of adaptive immunity in children and adolescents suffering from migraine; however, a transient decrease of CD8(+) prevalence during the ictal phase was detected irrespective of the subtype of migraine.
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