ReviewNature reviews. Microbiology2012
From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?
Review in Nature reviews. Microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Article
- Phosphate sensing by PhoPR regulates the cytotoxicity ofMicrobiology (Reading, England) · 2025Article
- Article
- A multicenter study on accuracy and reproducibility of nanopore sequencing-based genotyping of bacterial pathogens.Journal of clinical microbiology · 2024Article
- The role of Staphylococcus aureus quorum sensing in cutaneous and systemic infections.Inflammation and regeneration · 2024Review
- The major role ofVirulence · 2023Article
- Complex Regulation of Gamma-Hemolysin Expression Impacts Staphylococcus aureus Virulence.Microbiology spectrum · 2023Article
- Limiting protease production plays a key role in the pathogenesis of the divergent clinical isolates ofVirulence · 2021Article
- Review
- Clinical and Microbiological Characteristics of Hospital-Acquired Methicillin-ResistantOpen forum infectious diseases · 2021Article
- Genotypic and Phenotypic Characterization ofToxins · 2021Observational
- Article
- SarA plays a predominant role in controlling the production of extracellular proteases in the diverse clinical isolates ofVirulence · 2020Article
- The general stress response ofMicrobiology (Reading, England) · 2020Article
- Silence as a way of niche adaptation: mecC-MRSA with variations in the accessory gene regulator (agr) functionality express kaleidoscopic phenotypes.Scientific reports · 2020Article
- Exploiting Correlations between Protein Abundance and the Functional Status ofACS infectious diseases · 2020Article
- The Impacts ofInfection and immunity · 2020Article
- Article
- Coagulase-Negative Staphylococci Pathogenomics.International journal of molecular sciences · 2019Review
- ClinicalToxins · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.