ArticleClinics (Sao Paulo, Brazil)2012
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents.
Article in Clinics (Sao Paulo, Brazil), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Experimental models in diabetes research.Laboratory animal research · 2026Review
- Review
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- Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview.Toxicology reports · 2021Review
- Ncl1-mediated metabolic rewiring critical during metabolic stress.Life science alliance · 2019Article
- Extensive use of monosodium glutamate: A threat to public health?EXCLI journal · 2018Article
- Cardiovascular research in CLINICS.Clinics (Sao Paulo, Brazil) · 2013Article
- Commentary on: "Further studies are necessary in order to conclude a causal association between the consumption of monosodium L-glutamate (MSG) and the prevalence of the metabolic syndrome in the rural Thai population".Nutrition & metabolism · 2013Article
- Cardiovascular changes in animal models of metabolic syndrome.Journal of diabetes research · 2013Article
- Differences in the mechanisms that induce obesity and metabolic syndrome in experimental animal models and humans may cause treatment failure.Clinics (Sao Paulo, Brazil) · 2013Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life.
methodThe animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol.
resultsBody weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (>7 times), bradycardic responses (>4 times), and vagal (~38%) and sympathetic effects (~36%) were reduced as compared to the control group.
conclusionOur results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance.
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