Evidence map›Paper›PMID 23070341›Full record

Trial reportClinics (Sao Paulo, Brazil)2012

Intraoperative fluid management in open gastrointestinal surgery: goal-directed versus restrictive.

Jun Zhang, Hui Qiao, Zhiyong He, Yun Wang, Xuehua Che, Weimin Liang

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinics (Sao Paulo, Brazil), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07438249 (Intraoperative Goal-Directed Fluid Therapy and Postoperative Cognitive Outcomes in Geriatric Patients Undergoing Major Cancer Surgeries), which is not on this map. Cited by 28 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 10 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07438249 completednot on this mapstarted 2024, after this paper: background citation

Intraoperative Goal-Directed Fluid Therapy and Postoperative Cognitive Outcomes in Geriatric Patients Undergoing Major Cancer Surgeries: A Comparative Study

TypeobservationalSponsorDr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalRan2024 to 2026Enrolled180ConditionsPostoperative Cognitive Dysfunction, Geriatrics, Abdominal Neoplasm, HemodynamicsArmsMasimo Root Hemodynamic Monitoring
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 10 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jun ZhangDepartment of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China. snapzhang@yahoo.com.cn
Hui Qiao
Zhiyong He
Yun Wang
Xuehua Che
Weimin Liang
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe optimal strategy for fluid management during gastrointestinal surgery remains unclear. Minimizing the variation in arterial pulse pressure, which is induced by mechanical ventilation, is a potential strategy to improve postoperative outcomes. We tested this hypothesis in a prospective, randomized study with lactated Ringer's solution and 6% hydroxyethyl starch solution.

methodA total of 60 patients who were undergoing gastrointestinal surgery were randomized into a restrictive lactated Ringer's group (n = 20), a goal-directed lactated Ringer's group (n = 20) and a goal-directed hydroxyethyl starch group (n = 20). The goal-directed fluid treatment was guided by pulse pressure variation, which was recorded during surgery using a simple manual method with a Datex Ohmeda S/5 Monitor and minimized to 11% or less by volume loading with either lactated Ringer's solution or 6% hydroxyethyl starch solution (130/0.4). The postoperative flatus time, the length of hospital stay and the incidence of complications were recorded as endpoints.

resultsThe goal-directed lactated Ringer's group received the greatest amount of total operative fluid compared with the two other groups. The flatus time and the length of hospital stay in the goal-directed hydroxyethyl starch group were shorter than those in the goal-directed lactated Ringer's group and the restrictive lactated Ringer's group. No significant differences were found in the postoperative complications among the three groups.

conclusionMonitoring and minimizing pulse pressure variation by 6% hydroxyethyl starch solution (130/0.4) loading during gastrointestinal surgery improves postoperative outcomes and decreases the discharge time of patients who are graded American Society of Anesthesiologists physical status I/II.

Indexed as

AdultAgedAnalysis of VarianceBlood PressureDigestive System Surgical ProceduresFemaleFluid TherapyHumansHydroxyethyl Starch DerivativesIntraoperative PeriodIsotonic SolutionsLength of StayMaleMiddle AgedPostoperative PeriodRinger's SolutionHydroxyethyl Starch DerivativesIsotonic SolutionsRinger's Solution

Identifiers

PMID23070341
PMCPMC3460017
OpenAlexW2109967415

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.