ArticleAntimicrobial agents and chemotherapy2013
Comparative sequence analysis of a multidrug-resistant plasmid from Aeromonas hydrophila.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 96 citations in OpenAlex.
- Genetic Elements Associated with the Acquired Resistome of the Gut Microbiota in a Broiler Rooster Flock in Hungary.Animals : an open access journal from MDPI · 2026Article
- Prevalence, multidrug resistance patterns, virulence and antimicrobial resistance genes of emerging MDR Aeromonas hydrophila strains retrieved from subclinical bovine mastitis.Scientific reports · 2026Article
- Development of an efficient recombineering system for Aeromonas.BMC microbiology · 2026Article
- Clinical emergence of a novel sequence type (ST3672) NDM-1-producingFrontiers in microbiology · 2026Article
- The association between the genetic structures of commonly incompatible plasmids in Gram-negative bacteria, their distribution and the resistance genes.Frontiers in cellular and infection microbiology · 2024Review
- Whole genome sequence analysis ofFrontiers in microbiology · 2023Article
- Prevalence and genetic diversity ofFrontiers in microbiology · 2022Article
- Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium.Scientific reports · 2021Article
- Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.Scientific reports · 2021Article
- Molecular and Functional Characterization of a Novel Plasmid-BorneInfection and drug resistance · 2021Article
- Article
- Complete genome sequence of fish-pathogenic Aeromonas hydrophila HX-3 and a comparative analysis: insights into virulence factors and quorum sensing.Scientific reports · 2020Article
- Isolation and characterization of bacteriophages against virulent Aeromonas hydrophila.BMC microbiology · 2020Article
- Characterization of IncC Plasmids in Enterobacterales of Food-Producing Animals Originating From China.Frontiers in microbiology · 2020Article
- AnAIMS microbiology · 2020Review
- Molecular characterization and expression analysis of two peptidoglycan recognition proteins (CcPGRP5, CcPGRP6) in larvae ontogeny of common carp Cyprinus carpio L. and upon immune stimulation by bacteria.BMC veterinary research · 2019Article
- Type 1, 2, and 1/2-Hybrid IncC Plasmids From China.Frontiers in microbiology · 2019Article
- Genetic Characterization ofFrontiers in microbiology · 2019Article
- Comparative genome analysis provides deep insights into Aeromonas hydrophila taxonomy and virulence-related factors.BMC genomics · 2018Article
- Plasmid-Mediated Quinolone Resistance (PMQR) Genes and Class 1 Integrons in Quinolone-Resistant Marine Bacteria and Clinical Isolates of Escherichia coli from an Aquacultural Area.Microbial ecology · 2018Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aeromonas hydrophila is a pathogenic bacterium that has been implicated in fish, animal, and human disease. Recently, a multidrug resistance (MDR) plasmid, pR148, was isolated from A. hydrophila obtained from a tilapia (Oreochromis niloticus) farm in Thailand. pR148 is a 165,906-bp circular plasmid containing 147 coding regions showing highest similarity to pNDM-1_Dok1, an MDR plasmid isolated from a human pathogen. pR148 was also very similar to other IncA/C plasmids isolated from humans, animals, food, and fish. pR148 contains a mercuric resistance operon and encodes the complete set of genes for the type 4 secretion system. pR148 encodes a Tn21 type transposon. This transposon contains the drug resistance genes qacH, bla(OXA-10), aadA1, and sul1 in a class 1 integron; tetA and tetR in transposon Tn1721; and catA2 and a duplicate sul1 in a locus showing 100% similarity to IncU plasmids isolated from fish. The bla(OXA-10) and aadA1 genes showed 100% similarity to those from the Acinetobacter baumannii AYE genome. The similarity of pR148 to a human pathogen-derived plasmid indicates that the plasmids were either transferred between different genera or that they are derived from a common origin. Previous studies have shown that IncA/C plasmids retain a conserved backbone, while the accessory region points to lateral gene transfer. These observations point out the dangers of indiscriminate use of antibiotics in humans and in animals and the necessity of understanding how drug resistance determinants are disseminated and transferred.
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