ArticleThe Journal of investigative dermatology2012
Activation of the unfolded protein response in vitiligo: the missing link?
Article in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Oral gliadin-protected superoxide dismutase in addition to phototherapy for treating non-segmental vitiligo: A 24-week prospective randomized placebo-controlled study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Trial
- Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study.The Journal of investigative dermatology · 2015Trial
- The Pathogenesis and Management of Vitiligo.Cureus · 2024Review
- Serum Inflammatory and Oxidative Stress Markers in Patients with Vitiligo.Journal of clinical medicine · 2023Article
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- Vitiligo, from Pathogenesis to Therapeutic Advances: State of the Art.International journal of molecular sciences · 2023Review
- NRF2 in the Epidermal Pigmentary System.Biomolecules · 2022Review
- Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point.Clinical reviews in allergy & immunology · 2022Review
- The Promising Role of Chemokines in Vitiligo: From Oxidative Stress to the Autoimmune Response.Oxidative medicine and cellular longevity · 2022Review
- Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments.International journal of molecular sciences · 2021Review
- Targeting Innate Immunity to Combat Cutaneous Stress: The Vitiligo Perspective.Frontiers in immunology · 2021Review
- BMP4-Induced Differentiation of Human Hair Follicle Neural Crest Stem Cells into Precursor Melanocytes from Hair Follicle Bulge.Annals of dermatology · 2020Article
- Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity.Medical science monitor : international medical journal of experimental and clinical research · 2019Review
- Transcriptional Analysis of Vitiligo Skin Reveals the Alteration of WNT Pathway: A Promising Target for Repigmenting Vitiligo Patients.The Journal of investigative dermatology · 2015Article
- Melanocyte Regeneration in Vitiligo Requires WNT beneath their Wings.The Journal of investigative dermatology · 2015Article
- Simvastatin prevents and reverses depigmentation in a mouse model of vitiligo.The Journal of investigative dermatology · 2015Article
- CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo.Science translational medicine · 2014Article
- Vitiligo and alopecia areata: apples and oranges?Experimental dermatology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitiligo is characterized by a substantial loss of functional melanocytes in the epidermis and sometimes in hair follicles. Genetic and pathophysiological studies have provided strong evidence that vitiligo is a polygenetic, multifactorial disorder. The key roles of oxidative stress within melanocytes and anti-melanocyte immune responses have been addressed in many studies, but the relationship between these mechanisms remains unclear. In this issue, Toosi et al. report the upregulation of IL-6 and IL-8 after the activation of the unfolded protein response (UPR) following exposure of melanocytes to phenols. Their results shed light on the missing link between oxidative stress and immune responses in vitiligo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.