ArticleDiabetes care2013
Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
107 citing papers in PubMed, 3 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010.Current obesity reports · 2023Pooled it
- Perceived stress and diet quality in women of reproductive age: a systematic review and meta-analysis.Nutrition journal · 2020Pooled it
- Food cue reactivity and craving predict eating and weight gain: a meta-analytic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016Pooled it
- Trial
- Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge-Eating Disorder.The International journal of eating disorders · 2024Trial
- Oxytocin reduces the functional connectivity between brain regions involved in eating behavior in men with overweight and obesity.International journal of obesity (2005) · 2020Trial
- Associations of Brain Reactivity to Food Cues with Weight Loss, Protein Intake and Dietary Restraint during the PREVIEW Intervention.Nutrients · 2018Trial
- The Effects of Experimental Manipulation of Sleep Duration on Neural Response to Food Cues.Sleep · 2017Trial
- A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation.Journal of psychopharmacology (Oxford, England) · 2015Trial
- An eight month randomized controlled exercise intervention alters resting state synchrony in overweight children.Neuroscience · 2014Trial
- Monetary reward processing in obese individuals with and without binge eating disorder.Biological psychiatry · 2013Trial
- Prevalence and Correlates of Perceived Food Noise Among U.S. Adults in a Nationally Representative Sample.Obesity science & practice · 2026Article
- Naltrexone/bupropion for binge-eating disorder: A human laboratory investigation of mechanisms.Drug and alcohol dependence reports · 2026Article
- Article
- The Association Between Traumatic Experiences and Weight Loss Outcomes in Obesity.Noro psikiyatri arsivi · 2026Article
- Daytime sleepiness and specific food cravings: The moderating role of insulin sensitivity.PloS one · 2026Article
- Evidence for food-related and non-food-related maladaptive preference in a mouse model of binge eating disorder.Frontiers in behavioral neuroscience · 2025Article
- The battle over "food addiction".Frontiers in psychiatry · 2025Review
- Body mass, neuro-hormonal stress processing, and disease activity in lean to obese people with multiple sclerosis.Journal of neurology · 2024Article
- Trait food craving predicts functional connectivity between dopaminergic midbrain and the fusiform food area during eating imagery.Frontiers in psychiatry · 2024Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveObesity is associated with alterations in corticolimbic-striatal brain regions involved in food motivation and reward. Stress and the presence of food cues may each motivate eating and engage corticolimibic-striatal neurocircuitry. It is unknown how these factors interact to influence brain responses and whether these interactions are influenced by obesity, insulin levels, and insulin sensitivity. We hypothesized that obese individuals would show greater responses in corticolimbic-striatal neurocircuitry after exposure to stress and food cues and that brain activations would correlate with subjective food craving, insulin levels, and HOMA-IR. RESEARCH DESIGN AND
methodsFasting insulin levels were assessed in obese and lean subjects who were exposed to individualized stress and favorite-food cues during functional MRI.
resultsObese, but not lean, individuals exhibited increased activation in striatal, insular, and hypothalamic regions during exposure to favorite-food and stress cues. In obese but not lean individuals, food craving, insulin, and HOMA-IR levels correlated positively with neural activity in corticolimbic-striatal brain regions during favorite-food and stress cues. The relationship between insulin resistance and food craving in obese individuals was mediated by activity in motivation-reward regions including the striatum, insula, and thalamus.
conclusionsThese findings demonstrate that obese, but not lean, individuals exhibit increased corticolimbic-striatal activation in response to favorite-food and stress cues and that these brain responses mediate the relationship between HOMA-IR and food craving. Improving insulin sensitivity and in turn reducing corticolimbic-striatal reactivity to food cues and stress may diminish food craving and affect eating behavior in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.