ArticleDiabetes care2013
Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets.The Journal of clinical endocrinology and metabolism · 2016Trial
- Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.The American journal of clinical nutrition · 2016Trial
- Non-contrast CT-based radiomics nomogram of pericoronary adipose tissue for predicting haemodynamically significant coronary stenosis in patients with type 2 diabetes.BMC medical imaging · 2023Article
- Cardiovascular disease in diabetes, beyond glucose.Cell metabolism · 2021Review
- A diabetes-associated genetic variant is associated with diastolic dysfunction and cardiovascular disease.ESC heart failure · 2020Article
- Coagulatory Defects in Type-1 and Type-2 Diabetes.International journal of molecular sciences · 2019Review
- Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes.Cardiovascular diabetology · 2019Observational
- Type 2 Diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links.Frontiers in endocrinology · 2018Review
- Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.Circulation. Cardiovascular genetics · 2015Article
- Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study.Diabetes care · 2014Article
- Genetic insights into cardiometabolic risk factors.The Clinical biochemist. Reviews · 2014Review
- Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease.Current cardiovascular risk reports · 2014Article
- Introduction to personalized medicine in diabetes mellitus.Rambam Maimonides medical journal · 2014Article
- Insights into the genetic basis of type 2 diabetes.Journal of diabetes investigation · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D. RESEARCH DESIGN AND
methodsThe current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetes-predisposing variants.
resultsEach additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01). We also found that the GPS was positively associated with hemoglobin A(1c) levels (P = 0.009).
conclusionsGenetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D.
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Registered trials
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