ReviewMolecular aspects of medicine2013
'Metabolically healthy obesity': origins and implications.
Review in Molecular aspects of medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05591339 (Diabetes Diagnosis, Management, Prevention and Education in Guinea-Bissau), which is not on this map. Cited by 87 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diabetes Diagnosis, Management, Prevention and Education in Guinea-Bissau
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies.Molecular psychiatry · 2014Pooled it
- Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study.Genome medicine · 2022Trial
- Inflammatory cytokines in general and central obesity and modulating effects of physical activity.PloS one · 2015Trial
- Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome.Nature metabolism · 2026Article
- Does metabolically healthy obesity increase the risk of knee and hand osteoarthritis? A population-based cohort study.BMC musculoskeletal disorders · 2026Article
- The role of body composition in neurological and hematologic toxicity in a retrospective analysis of 120 breast cancer patients undergoing neoadjuvant chemotherapy: the COMBOTOX study.Breast cancer research and treatment · 2025Observational
- Orbital Fat is an Observation Model to Provide Insights into Adipocyte Hypertrophy and Hyperplasia During White Adipose Tissue Expansion.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Lack of adipocyte FAM20C improves whole body glucose homeostasis.Physiological reports · 2024Article
- Diet-induced obesity affects influenza disease severity and transmission dynamics in ferrets.Science advances · 2024Article
- Article
- Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations.JCI insight · 2024Article
- Association of obesity under different metabolic status with adverse outcomes in patients with chronic myeloid leukemia: A retrospective cohort study.Journal of diabetes · 2023Article
- Association between metabolically healthy overweight/obesity and gallstones in Chinese adults.Nutrition & metabolism · 2023Article
- Article
- Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance.Metabolites · 2023Review
- Bariatric surgery and calcifediol treatment, Gordian knot of severe-obesity-related comorbidities treatment.Frontiers in endocrinology · 2023Article
- Bariatric surgery and its impact on depressive symptoms, cognition, brain and inflammation.Frontiers in endocrinology · 2023Article
- Global Single-Cell Sequencing Landscape of Adipose Tissue of Different Anatomical Site Origin in Humans.Stem cells international · 2023Article
- Article
- BMI Modifies Increased Mortality Risk of Post-PCI STEMI Patients with AKI.Journal of clinical medicine · 2022Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
When humans eat more and exercise less, they tend to become obese and unhealthy. The molecular pathways that link obesity to serious diseases like Type 2 diabetes and cardiovascular disease have become a subject of intensive scientific investigation because the exploding prevalence of obesity worldwide represents a grave new threat to the health of hundreds of millions of people. However, obesity is not always destiny. Two important clinical populations have been valuable to understand the mechanisms behind this conundrum: individuals who exhibit metabolic dysfunction, diabetes and elevated cardiovascular disease risk despite a lean body type, and individuals who are relatively protected from these dangers despite significant obesity. Study of this second group of 'metabolically healthy obese' people in particular has been revealing because such individuals exhibit specific, identifiable, anatomic, cellular and molecular features that set them apart from the rest of us who suffer declining health with increasing weight. Here, we examine some of these features, including some mouse models that are informative of mechanism, and suggest hypotheses for further study, including the possibility that genes and pathways of the immune system might offer new diagnostic or therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.