Trial reportBMC medicine2012
Effect of a multifactorial interdisciplinary intervention on mobility-related disability in frail older people: randomised controlled trial.
Trial report in BMC medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 14 syntheses or guidelines pooled it.
- Current evidence on the core components of the geriatric rehabilitation process: a systematic review.Aging clinical and experimental research · 2026Pooled it
- Effects of exercise interventions on physical function, cognitive function and quality of life of frail older adults in nursing homes: a systematic review and meta-analysis.Frontiers in psychology · 2025Pooled it
- Community-based complex interventions to sustain independence in older people, stratified by frailty: a systematic review and network meta-analysis.Health technology assessment (Winchester, England) · 2024Pooled it
- Frailty as an Effect Modifier in Randomized Controlled Trials: A Systematic Review.Journal of general internal medicine · 2024Pooled it
- Mobility training for increasing mobility and functioning in older people with frailty.The Cochrane database of systematic reviews · 2022Pooled it
- Using Patient- and Family-Reported Outcome and Experience Measures Across Transitions of Care for Frail Older Adults Living at Home: A Meta-Narrative Synthesis.The Gerontologist · 2021Pooled it
- Pooled it
- Safety and Effectiveness of Long-Term Exercise Interventions in Older Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis.PloS one · 2020Pooled it
- Delaying and reversing frailty: a systematic review of primary care interventions.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Pooled it
- Interventions for frail community-dwelling older adults have no significant effect on adverse outcomes: a systematic review and meta-analysis.BMC geriatrics · 2018Pooled it
- Do Exercise Interventions Improve Participation in Life Roles in Older Adults? A Systematic Review and Meta-Analysis.Physical therapy · 2017Pooled it
- Relationship between family caregiver burden and physical frailty in older adults without dementia: a systematic review.Systematic reviews · 2017Pooled it
- Effects of multi-domain interventions in (pre)frail elderly on frailty, functional, and cognitive status: a systematic review.Clinical interventions in aging · 2017Pooled it
- Trial
- Home-Based Intervention to Prevent Functional Decline in (Pre)frail Older Adults: The PromeTheus Randomized Controlled Trial.Journal of cachexia, sarcopenia and muscle · 2026Trial
- Out-of-home mobility enhancement by a physiotherapist-led motivational counselling intervention among rural community-dwelling older adults 75+: the MOBILE RCT.BMC geriatrics · 2026Trial
- Global Positioning System Indicators of Community Mobility and Future Health Outcomes Among Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Disability Prevention Program Improves Life-Space and Falls Efficacy: A Randomized Controlled Trial.Journal of the American Geriatrics Society · 2021Trial
- The Effectiveness of a PRoactive Multicomponent Intervention Program on Disability in Independently Living Older People: A Randomized Controlled Trial.The journal of nutrition, health & aging · 2018Trial
11 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
Abstract
backgroundInterventions that enhance mobility in frail older people are needed to maintain health and independence, yet definitive evidence of effective interventions is lacking. Our objective was to assess the impact of a multifactorial intervention on mobility-related disability in frail older people.
methodsWe conducted a randomised, controlled trial with 241 frail community-dwelling older people in Sydney, Australia. Participants were classified as frail using the Cardiovascular Health Study definition, did not have severe cognitive impairment and were recently discharged from an aged care and rehabilitation service. The experimental group received a 12 month multifactorial, interdisciplinary intervention targeting identified frailty components. Two physiotherapists delivered a home exercise program targeting mobility, and coordinated management of psychological and medical conditions with other health professionals. The control group received usual care. Disability in the mobility domain was measured at baseline and at 3 and 12 months using the International Classification of Functioning, Disability and Health framework. Participation (involvement in life situations) was assessed using the Life Space Assessment and the Goal Attainment Scale. Activity (execution of mobility tasks) was measured using the 4-metre walk and self-report measures.
resultsThe mean age of participants was 83.3 years (SD: 5.9 years). Of the participants recruited, 216 (90%) were followed-up at 12 months. At this time point, the intervention group had significantly better scores than the control group on the Goal Attainment Scale (odds ratio 2.1; 95% confidence interval (CI) 1.3 to 3.3, P = 0.004) and Life Space Assessment (4.68 points, 95% CI 1.4 to 9.9, P = 0.005). There was no difference between groups on the global measure of participation or satisfaction with ability to get out of the house. At the activity level, the intervention group walked 0.05 m/s faster over 4 m (95% CI 0.0004 to 0.1, P = 0.048) than the control group, and scored higher on the Activity Measure for Post Acute Care (P < 0.001).
conclusionsThe intervention reduced mobility-related disability in frail older people. The benefit was evident at both the participation and activity levels of mobility-related disability.
trial registrationAustralia and New Zealand Clinical Trials Register (ANZCTR): ANZCTRN12608000507381.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.