ArticleHelicobacter2013
Intact long-type dupA as a marker for gastroduodenal diseases in Okinawan subpopulation, Japan.
Article in Helicobacter, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity.Infection · 2024Pooled it
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- Overview ofGut and liver · 2021Review
- Helicobacter pylori type 4 secretion systems as gastroduodenal disease markers.Scientific reports · 2021Article
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- Novel virulence factorWorld journal of gastroenterology · 2020Review
- The role of integrating conjugative elements in Helicobacter pylori: a review.Journal of biomedical science · 2018Review
- Current understanding and management ofF1000Research · 2018Review
- Role ofWorld journal of gastroenterology · 2016Review
- Article
- Helicobacter pylori with the Intact dupA Cluster is more Virulent than the Strains with the Incomplete dupA Cluster.Current microbiology · 2015Article
- Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests.Epidemiology and infection · 2015Article
- Differences in interleukin 8 expression in Helicobacter pylori-infected gastric mucosa tissues from patients in Bhutan and the Dominican Republic.Human pathology · 2015Article
- Helicobacter pylori virulence genes in the five largest islands of Indonesia.Gut pathogens · 2015Article
- Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population.Gut pathogens · 2015Article
- Helicobacter pylori virulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease.Expert review of gastroenterology & hepatology · 2015Review
- Helicobacter pylori virulence and cancer pathogenesis.Future oncology (London, England) · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundHelicobacter pylori dupA can be divided into two types according to the presence or absence of the mutation. In addition, full-sequenced data revealed that dupA has two types with different lengths depend on the presence of approximately 600 bp in the putative 5' region (presence; long-type and absence; short-type), which has not been taken into account in previous studies.
methodsA total of 319 strains isolated from Okinawa, the south islands of Japan, were included. The status of dupA and cagA was determined by polymerase chain reaction. The presence of mutations in long-type dupA was determined by DNA sequencing.
resultsThe prevalence of long-type dupA was 26.3% (84/319). Sequence analysis showed that there were only six cases (7.1%) with point mutations lead to stop codon among 84 long-type dupA strains studied. Interestingly, intact long-type dupA without frameshift mutation, but not short-type dupA, was significantly associated with gastric ulcer and gastric cancer than gastritis (p = .001 and p = .019, respectively). After adjustment by age, gender, and cagA, the presence of intact long-type dupA was significantly associated with gastric ulcer and gastric cancer compared with gastritis (odds ratio [OR] = 3.35, 95% confidence interval [CI] = 1.55-7.24 and OR = 4.14, 95% CI = 1.23-13.94, respectively).
conclusionsIntact long-type dupA is a real virulence marker for severe outcomes in Okinawa, Japan. The previous information gained from PCR-based methods without taking long-type dupA into account must be interpreted with caution.
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