ReviewJournal of cardiovascular electrophysiology2012
New advances in the genetic basis of atrial fibrillation.
Review in Journal of cardiovascular electrophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Transcriptomic Landscape of Human Left and Right Atria Associated with Atrial Fibrillation.Anatolian journal of cardiology · 2025Article
- Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease.Stem cell research & therapy · 2023Article
- A Discussion of the Contemporary Prediction Models for Atrial Fibrillation.Medical research archives · 2023Article
- Transcriptional factors in calcium mishandling and atrial fibrillation development.Pflugers Archiv : European journal of physiology · 2021Review
- Afterdepolarizations and abnormal calcium handling in atrial myocytes with modulated SERCA uptake: a sensitivity analysis of calcium handling channels.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.The Journal of clinical investigation · 2019Article
- Early repolarization pattern as a predictor of atrial fibrillation recurrence following radiofrequency pulmonary vein isolation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
- Significant association of rare variant p.Gly8Ser in cardiac sodium channel β4-subunit SCN4B with atrial fibrillation.Annals of human genetics · 2019Article
- Electrocardiogram (ECG) for the Prediction of Incident Atrial Fibrillation: An Overview.Journal of atrial fibrillation · 2017Review
- Multiple Roles of Pitx2 in Cardiac Development and Disease.Journal of cardiovascular development and disease · 2017Review
- PITX2-dependent gene regulation in atrial fibrillation and rhythm control.The Journal of physiology · 2017Review
- Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review.Frontiers in public health · 2017Review
- The rs6817105 polymorphism on chromosome 4q25 is associated with the risk of atrial fibrillation in the Chinese Han population.Anatolian journal of cardiology · 2016Article
- Association of genetic variants with atrial fibrillation.Biomedical reports · 2016Article
- Common Variants in the TBX5 Gene Associated with Atrial Fibrillation in a Chinese Han Population.PloS one · 2016Article
- The role of transcription factors in atrial fibrillation.Journal of thoracic disease · 2015Review
- Pitx2, an atrial fibrillation predisposition gene, directly regulates ion transport and intercalated disc genes.Circulation. Cardiovascular genetics · 2014Article
- Weighted gene coexpression network analysis of human left atrial tissue identifies gene modules associated with atrial fibrillation.Circulation. Cardiovascular genetics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Over the past decade, compelling evidence has emerged from population-based studies to suggest that AF is a heritable disease. More recently, we have begun to elucidate the genetic substrate underlying AF. Genome-wide association studies (GWAS) have led to the identification of multiple risk loci that confer increased susceptibility to the arrhythmia. These loci harbor intriguing candidate genes including those encoding ion channels, transcription factors, and signaling molecules. Current efforts are ongoing to functionally validate the role of these genes in disease pathogenesis. In the future, novel genotyping technologies such as exome sequencing and whole-genome sequencing promise to uncover a greater proportion of the heritability underlying AF. In this article we review recent advances in AF genetics research and discuss future developments in the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.