ReviewInternational journal of environmental research and public health2012
Leukemia and benzene.
Review in International journal of environmental research and public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 271 citations in OpenAlex.
- Occupational Exposure to Benzene and Risk of Breast Cancer: Systematic Review and Meta-Analysis.La Medicina del lavoro · 2024Pooled it
- Occupational benzene exposure and the risk of genetic damage: a systematic review and meta-analysis.BMC public health · 2020Pooled it
- A review and meta-analysis of outdoor air pollution and risk of childhood leukemia.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2015Pooled it
- Changes in biomarkers of exposure and withdrawal symptom among Chinese adult smokers after completely or partially switching from combustible cigarettes to an electronic nicotine delivery system.Internal and emergency medicine · 2024Trial
- Linking Air Pollution and Hematologic Malignancies: From Epidemiology to Molecular Mechanisms.Current hematologic malignancy reports · 2026Review
- Volatile Organic Compound Metabolites Are Found in the Urine of Breastfed Infants Whose Mothers Use Cannabis: The Lactation and Cannabis (LAC) Study.International journal of environmental research and public health · 2026Article
- Benzene and other hazardous air pollutants in consumer-grade natural gas in Europe.Environmental research letters : ERL [Web site] · 2026Article
- Association Between Petroleum Compounds Exposure and Risk of Childhood Leukemia: A Systematic Review.Blood and lymphatic cancer : targets and therapy · 2026Review
- Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.Journal of xenobiotics · 2025Review
- The association between air pollution exposure and childhood cancer: a scoping review about the challenges in epidemiological studies.BMC public health · 2025Article
- Nanoencapsulation of ferrocene incorporated thiourea and doxorubicin for treatment of acute myeloid leukemia.BMC cancer · 2025Article
- BTEX chrono-metabolism and leukemogenic effects of night shift work in workers of gasoline stations: the EXPOSOWORK prospective panel study in Bulgaria.Journal of the National Cancer Center · 2025Article
- The Evolving Industrial Landscape in Occupational Chronic Benzene Poisoning - 6 PLADs, China, 2020-2023.China CDC weekly · 2025Article
- Association Between Blood Benzene Levels and Periodontal Disease in a Nationally Representative Adult U.S. Population.International journal of environmental research and public health · 2025Article
- Cumulative Human Health Risk Assessment of Regional Ozone and Volatile Organic Compounds from Unconventional Oil and Gas Sites in Colorado's Front Range.Environmental health perspectives · 2025Article
- Article
- Myelodysplastic syndromes among atomic bomb survivors in Nagasaki: similarities to and differences from de novo and therapy-related cases.Journal of radiation research · 2024Review
- Recent Developments in Aptamer-Based Sensors for Diagnostics.Sensors (Basel, Switzerland) · 2024Review
- Mediating effect of oxidative stress on blood pressure elevation in workers exposed to low concentrations of benzene, toluene, and xylene (BTX).Scientific reports · 2024Article
- Arylpiperazine Derivatives and Cancer: A New Challenge in Medicinal Chemistry.Pharmaceuticals (Basel, Switzerland) · 2024Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive exposure to benzene has been known for more than a century to damage the bone marrow resulting in decreases in the numbers of circulating blood cells, and ultimately, aplastic anemia. Of more recent vintage has been the appreciation that an alternative outcome of benzene exposure has been the development of one or more types of leukemia. While many investigators agree that the array of toxic metabolites, generated in the liver or in the bone marrow, can lead to traumatic bone marrow injury, the more subtle mechanisms leading to leukemia have yet to be critically dissected. This problem appears to have more general interest because of the recognition that so-called "second cancer" that results from prior treatment with alkylating agents to yield tumor remissions, often results in a type of leukemia reminiscent of benzene-induced leukemia. Furthermore, there is a growing literature attempting to characterize the fine structure of the marrow and the identification of so called "niches" that house a variety of stem cells and other types of cells. Some of these "niches" may harbor cells capable of initiating leukemias. The control of stem cell differentiation and proliferation via both inter- and intra-cellular signaling will ultimately determine the fate of these transformed stem cells. The ability of these cells to avoid checkpoints that would prevent them from contributing to the leukemogenic response is an additional area for study. Much of the study of benzene-induced bone marrow damage has concentrated on determining which of the benzene metabolites lead to leukemogenesis. The emphasis now should be directed to understanding how benzene metabolites alter bone marrow cell biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.