ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2012
Adaptive servoventilation in patients with central or complex sleep apnea related to chronic opioid use and congestive heart failure.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Medium Increased Risk for Central Sleep Apnea but Not Obstructive Sleep Apnea in Long-Term Opioid Users: A Systematic Review and Meta-Analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Pooled it
- Home-use servo-ventilation therapy in chronic pain patients with central sleep apnea: initial and 3-month follow-up.Sleep & breathing = Schlaf & Atmung · 2015Trial
- Trial
- Sleep-Disordered Breathing and Interactions with Opioids: A Narrative Review.Journal of clinical medicine · 2025Review
- Article
- Sleep-Related Breathing Disorders: When CPAP Is Not Enough.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Might chronic opioid use impact sleep-disordered breathing and vice versa?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Adaptive Servo-Ventilation: A Comprehensive Descriptive Study in the Geneva Lake Area.Frontiers in medicine · 2020Article
- Continuous Positive Airway Pressure and Adaptive Servoventilation in Heart Failure Patients With Central Sleep Apnea With Cheyne Stokes Respiration: Are They Useful in Ameliorating Cardiac Systolic Dysfunction?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Effects of Adaptive Servoventilation Therapy for Central Sleep Apnea on Health Care Utilization and Mortality: A Population-Based Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Article
- Adaptive servoventilation in clinical practice: beyond SERVE-HF?ERJ open research · 2017Article
- Clinical predictors of central sleep apnea evoked by positive airway pressure titration.Nature and science of sleep · 2016Article
- Adaptive servoventilation for treatment of opioid-associated central sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Article
- The epidemic of opioid use: implications for the sleep physician.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Article
- Positive airway pressure therapy in patients with opioid-related central sleep apnea.Sleep & breathing = Schlaf & Atmung · 2014Article
- Positive airway pressure treatment for opioid-related central sleep apnea, where are we now?Sleep & breathing = Schlaf & Atmung · 2014Article
- Analysis of cardiopulmonary coupling to assess adaptive servo-ventilation success in complex sleep apnea management.Sleep & breathing = Schlaf & Atmung · 2013Article
- Complex sleep apnea syndrome.Patient preference and adherence · 2013Article
- Opioid-induced sleep apnea: is it a real problem?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2012Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesAdaptive servoventilation (ASV) is often used to treat central sleep apnea (CSA) and complex sleep apnea syndrome (CompSAS). Both CompSAS and CSA may occur in the setting of CHF and with the use of chronic opioids. We hypothesized that ASV would be less successful in treatment of CSA and CompSAS secondary to opioid use than in CHF patients.
methodsConsecutive patients were studied between January and December 2009 who underwent ASV titration for CSA or CompSAS due to CHF (defined as EF < 45%, or > 50% with evidence for diastolic dysfunction on echocardiogram) and chronic opioid users (defined by the use of opioids > 6 months).
resultsStudy included one hundred and eight patients with 77 males (71.3%) and 31 females (28.7%). Subjects had severe sleep apnea at baseline (AHI 45.6 ± 27.4) and inadequate control of sleep disordered breathing on CPAP (AHI 50.0 ± 32.2, CAI 36.6 ± 32). No significant differences were found between the groups in overall ASV success, defined as AHI < 10/h (p = 0.236). ASV was successful in 28 (59.6%) of those in the opioid group, compared to 43 (70.5%) of those in the CHF group. When ASV success was defined as AHI < 5/h at optimum EEP, there was again no significant difference between the groups (p-value = 0.812). Logistic regression showed unit increases in BMI, unit increases in HCO(3), and presence of CSR were each associated with decreased likelihood of ASV success.
conclusionWe did not find a statistically significant difference in the effectiveness of ASV between CHF patients and chronic opioid users, with the overall success rate approaching 70%, as defined by an AHI < 10/h. COMMENTARY: A commentary on this article appears in this issue on page 577.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.