ArticleWorld journal of gastroenterology2012
Gastric carcinogenesis.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between cadherin-17 expression and pathological characteristics of gastric cancer: a meta-analysis.World journal of gastroenterology · 2015Pooled it
- MTHFR C677T polymorphism contributes to the risk for gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- The polymorphism of methylenetetrahydrofolate reductase C677T but not A1298C contributes to gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Distribution and Clinical Impact ofAntibiotics (Basel, Switzerland) · 2025Article
- The antioxidant and selective apoptotic activities of modified auraptene-loaded graphene quantum dot nanoparticles (M-AGQD-NP).Discover oncology · 2024Article
- Safety of pylorus-preserving gastrectomy for gastric cancer combined with antral high-risk lesions: a comparison with endoscopic submucosal dissection.Surgical endoscopy · 2023Review
- Clinical Significance of Epstein-Barr Virus andGut and liver · 2023Article
- Kindlin1 As a Gender and Location-Specific Diagnostic Marker in Gastric Cancer Patients.Iranian journal of pathology · 2022Article
- Development and validation of an individual alternative splicing prognostic signature in gastric cancer.Aging · 2021Article
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- Ursolic Acid Inhibits Epithelial-Mesenchymal Transition through the Axl/NF-Evidence-based complementary and alternative medicine : eCAM · 2019Article
- High FNDC1 expression correlates with poor prognosis in gastric cancer.Experimental and therapeutic medicine · 2018Article
- Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.Yonsei medical journal · 2018Article
- The regulation and function of microRNA-377/RASSF8 signaling axis in gastric cancer.Oncology letters · 2018Article
- NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells.PloS one · 2018Article
- Gene Expression Analysis of Two Epithelial-mesenchymal Transition-related Genes: Long NoncodingAdvanced biomedical research · 2018Article
- Expression of NUAK2 in gastric cancer tissue and its effects on the proliferation of gastric cancer cells.Experimental and therapeutic medicine · 2017Article
- Positive feedback loop of IL-1β/Akt/RARα/Akt signaling mediates oncogenic property of RARα in gastric carcinoma.Oncotarget · 2017Article
- Organoid Models of Human Gastrointestinal Development and Disease.Gastroenterology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer is the second most common cancer worldwide and the second most common cause of cancer-related deaths. Despite complete resection of gastric cancer and lymph node dissection, as well as improvements in chemotherapy and radiotherapy, there are still 700,000 gastric cancer-related deaths per year worldwide and more than 80% of patients with advanced gastric cancer die of the disease or recurrent disease within 1 year after diagnosis. None of the treatment modalities we have been applying today can influence the overall survival rates: at present, the overall 5-year relative survival rate for gastric cancer is about 28%. Cellular metaplasia due to chronic inflammation, injury and repair are the most documented processes for neoplasia. It appears that chronic inflammation stimulates tumor development and plays a critical role in initiating, sustaining and advancing tumor growth. It is also evident that not all inflammation is tumorigenic. Additional mutations can be acquired, and this leads to the cancer cell gaining a further growth advantage and acquiring a more malignant phenotype. Intestinalization of gastric units, which is called "intestinal metaplasia"; phenotypic antralization of fundic units, which is called "spasmolytic polypeptide-expressing metaplasia"; and the development directly from the stem/progenitor cell zone are three pathways that have been described for gastric carcinogenesis. Also, an important factor for the development of gastrointestinal cancers is peritumoral stroma. However, the initiating cellular event in gastric metaplasia is still controversial. Understanding gastric carcinogenesis and its precursor lesions has been under intense investigation, and our paper attempts to highlight recent progress in this field of cancer research.
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