ReviewWorld journal of gastroenterology2012
Cell sheet technology for regeneration of esophageal mucosa.
Review in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- [Establishment of rabbit model of benign circumferential esophageal stricture].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Single-cell Technology in Stem Cell Research.Current stem cell research & therapy · 2025Review
- Simple and Cost-Effective Generation of 3D Cell Sheets and Spheroids Using Curvature-Controlled Paraffin Wax Substrates.Nano convergence · 2024Article
- Article
- Recent Advances in Cell Sheet Engineering: From Fabrication to Clinical Translation.Bioengineering (Basel, Switzerland) · 2023Review
- Scalable fabrication, compartmentalization and applications of living microtissues.Bioactive materials · 2023Article
- Clinical outcomes on weekly endoscopic dilations as the initial approach to manage patients with complex benign esophageal strictures: report on 488 dilations.Surgical endoscopy · 2022Article
- The Combination of Concentrated Growth Factor and Adipose-Derived Stem Cell Sheet Repairs Skull Defects in Rats.Tissue engineering and regenerative medicine · 2021Article
- Improvement of the therapeutic capacity of insulin-producing cells trans-differentiated from human liver cells using engineered cell sheet.Stem cell research & therapy · 2021Article
- Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature.Journal of clinical medicine · 2020Review
- Cell sheets of human dental pulp stem cells for future application in bone replacement.Clinical oral investigations · 2019Article
- Multilayered Engineered Tissue Sheets for Vascularized Tissue Regeneration.Tissue engineering and regenerative medicine · 2017Article
- Laminin-521 Promotes Rat Bone Marrow Mesenchymal Stem Cell Sheet Formation on Light-Induced Cell Sheet Technology.BioMed research international · 2017Article
- Preservation of epithelial progenitor cells from collagenase-digested oral mucosa during ex vivo cultivation.Scientific reports · 2016Article
- The application of cell sheet engineering in the vascularization of tissue regeneration.Regenerative medicine · 2016Review
- Brush biopsy of human oral mucosal epithelial cells as a quality control of the cell source for fabrication of transplantable epithelial cell sheets for regenerative medicine.Regenerative therapy · 2016Article
- Regenerative therapy by fusion of medicine and engineering: First-in-human clinical trials with induced pluripotent stem cells and cell sheet technology: A report of the Symposium of Regenerative Medicine for Patients.Regenerative therapy · 2015Article
- Odontogenic epithelial stem cells: hidden sources.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- Prevention of esophageal strictures after endoscopic submucosal dissection.World journal of gastroenterology · 2014Review
- Prevention and treatment of esophageal stenosis after endoscopic submucosal dissection for early esophageal cancer.Gastroenterology research and practice · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell- and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative medicine. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.