Trial reportThe Journal of clinical endocrinology and metabolism2012
Effects of gastric bypass surgery on female reproductive function.
Trial report in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- The magnitude and progress of lean body mass, fat-free mass, and skeletal muscle mass loss following bariatric surgery: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Impact of Bariatric Surgery on Female Sexual Function in Obese Patients: a Meta-Analysis.Obesity surgery · 2020Pooled it
- Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS.The Journal of clinical endocrinology and metabolism · 2016Trial
- The Pregnancy in Polycystic Ovary Syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trial.Fertility and sterility · 2014Trial
- Menstrual and Reproductive Function Before and After Metabolic Bariatric Surgery.Obesity surgery · 2026Article
- The influence of different bariatric surgeries on male sex hormones and semen parameters among infertile obese male patients: an observational study.BMC surgery · 2026Observational
- The Effects of Bariatric Surgery on Female Fertility: A Narrative Review.International journal of molecular sciences · 2026Review
- The Impact of Bariatric Surgery on the Development and Progression of Dermatologic Diseases: A Narrative Review.Dermatology and therapy · 2026Review
- Weight management in women of reproductive age.Obesity and endocrinology · 2026Review
- Implications of Metabolic Bariatric Surgery on Reproductive Health.Journal of clinical medicine · 2025Article
- The Relationship Between Obesity, Bariatric Surgery, and Infertility: A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Conceiving during the first postoperative year after bariatric surgery: a retrospective study of pregnancy outcomes.BMC pregnancy and childbirth · 2024Article
- Metabolic hormones are integral regulators of female reproductive health and function.Bioscience reports · 2024Review
- Obesity may impair response to ovarian stimulation. A retrospective observational study on oocyte quality.Frontiers in cell and developmental biology · 2024Article
- Review
- Outcome of Gastric Bypass Surgery on Patients with Polycystic Ovary Syndrome: A Review.Journal of clinical medicine · 2023Review
- Knowledge of Jordanian women of reproductive age who underwent bariatric surgery and its effect on birth outcomes: A cross-sectional study.SAGE open medicine · 2023Article
- The effects of bariatric surgery on male and female fertility: A systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2022Review
- Reproductive outcomes after bariatric surgery in women.Wiener klinische Wochenschrift · 2022Review
- Bariatric surgery and its impact on fertility, pregnancy and its outcome: A narrative review.Annals of medicine and surgery (2012) · 2021Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
contextReproductive function may improve after bariatric surgery, although the mechanisms and time-related changes are unclear.
objectiveThe objective of the study was to determine whether ovulation frequency/quality as well as associated reproductive parameters improve after Roux en Y gastric bypass surgery.
designThis was a prospective cohort study that enrolled female subjects from 2005 to 2008 with study visits at baseline and then 1, 3, 6, 12, and up to 24 months after surgery.
settingThe study was conducted at an academic health center. PATIENTS: Twenty-nine obese, reproductive-aged women not using confounding medications participated in the study.
main outcome measuresThe primary outcome was integrated levels of urinary progestin (pregnanediol 3-glururonide) from daily urinary collections at 12 months postoperatively. Secondary outcomes were changes in vaginal bleeding, other biometric, hormonal, ultrasound, dual-energy x-ray absorptiometry measures, and Female Sexual Function Index.
resultsNinety percent of patients with morbid obesity had ovulatory cycles at baseline, and the ovulatory frequency and luteal phase quality (based on integrated pregnanediol 3-glururonide levels) were not modified by bariatric surgery. The follicular phase was shorter postoperatively [6.5 d shorter at 3 months and 7.9-8.9 d shorter at 6-24 months (P < 0.01)]. Biochemical hyperandrogenism improved, largely due to an immediate postoperative increase in serum SHBG levels (P < 0.01), with no change in clinical hyperandrogenism (sebum production, acne, hirsutism). Bone density was preserved, contrasting with a significant loss of lean muscle mass and fat (P < 0.001), reflecting preferential abdominal fat loss (P < 0.001). Female sexual function improved 28% (P = 0.02) by 12 months.
conclusionsOvulation persists despite morbid obesity and the changes from bypass surgery. Reproductive function after surgery is characterized by a shortened follicular phase and improved female sexual function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.