ArticleNeuro-oncology2012
The effects of radiotherapy on psychosocial and cognitive functioning in adults with a primary brain tumor: a prospective evaluation.
Article in Neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Prediction Models for Radiation-Induced Neurocognitive Decline in Adult Patients With Primary or Secondary Brain Tumors: A Systematic Review.Frontiers in psychology · 2022Pooled it
- A Systematic Literature Review and Head-to-Head Comparison of Social Support and Social Constraint in Relation to the Psychological Functioning of Cancer Survivors.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020Pooled it
- Associations Between Malignant Tumors and Alzheimer's Disease: A Cross-Sectional Study.Brain and behavior · 2025Article
- Predicting attention deficits and functional recovery after glioma resection through functional executive networks: insights from dynamic properties.Journal of neuro-oncology · 2025Article
- Review
- Review
- Personalised support of brain tumour patients during radiotherapy based on psychological profile and quality of life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- The association between psychological functioning and social support and social constraint after cancer diagnosis: a 30-day daily diary study.Journal of behavioral medicine · 2021Article
- An Iatrogenic Model of Brain Small-Vessel Disease: Post-Radiation Encephalopathy.International journal of molecular sciences · 2020Review
- Post-traumatic stress disorders in patients with low-grade glioma and its association with survival.Journal of neuro-oncology · 2019Article
- Are we missing PTSD in our patients with cancer? Part I.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2019Article
- Psychosocial distress and its effects on the health-related quality of life of primary brain tumor patients.CNS oncology · 2016Review
- Trends in cognitive dysfunction following surgery for intracranial tumors.Surgical neurology international · 2016Article
- Acceptance and commitment therapy program for distressed adults with a primary brain tumor: a case series study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Psychotherapy Interventions for Managing Anxiety and Depressive Symptoms in Adult Brain Tumor Patients: A Scoping Review.Frontiers in oncology · 2015Article
- Screening for Psychological Distress in Adult Primary Brain Tumor Patients and Caregivers: Considerations for Cancer Care Coordination.Frontiers in oncology · 2015Review
- Work productivity and neuropsychological function in persons with skull base tumors.Neuro-oncology practice · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A paucity of studies have evaluated the biopsychosocial factors contributing to quality of life (QoL) in adults with a primary brain tumor (BT). Our objective was to investigate (i) the effects of radiotherapy on the psychosocial (ie, posttraumatic stress symptoms [PTSS]) and cognitive functioning of adults with a primary BT, assessed preradiotherapy [T1] and postradiotherapy [T2], and (ii) predictors of PTSS and QoL postradiotherapy. Seventy adults with a BT were assessed at T1, and 67 patients were reassessed 3.5 months postradiotherapy. At each assessment, participants completed measures of PTSS, mood, QoL, and quality of social support and neurocognitive tests focusing on memory and executive functioning. Minimal differences in functioning were found between patients according to BT type (benign [n = 45] vs malignant [n = 25]) and tumor laterality (left vs right hemisphere), with 2 exceptions. Individuals with a left hemisphere benign BT experienced greater distress at T1, which declined at T2, whereas individuals with a left hemisphere malignant BT reported poorer social support at T2. The full sample performed poorly on tests of executive functioning, and 17% reported clinically elevated PTSS at T1, which reduced to 13% at T2. Younger age (<65 y), reduced QoL, and elevated anger symptoms at T1 predicted PTSS at T2, whilst having a benign BT, low PTSS, and depressive symptoms at T1 were predictive of improved QoL at T2. Findings highlight the importance of screening for psychosocial and cognitive disturbances in BT patients undergoing treatment to identify those at risk for acute and more prolonged problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.