Trial reportCancer2013
Percutaneous image-guided cryoablation of painful metastases involving bone: multicenter trial.
Trial report in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 101 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases
Cone-beam Computed Tomography Guided Percutaneous Cryoablation of Bone Metastases From Endocrine Tumors
Who cites it
101 citing papers in PubMed, 6 syntheses or guidelines pooled it, 292 citations in OpenAlex.
- Percutaneous cryoablation in the management of spinal metastases: a comprehensive systematic review and meta-analysis.Journal of neuro-oncology · 2025Pooled it
- Image-guided cryoablation for palliation of painful bone metastases: a systematic review and meta-analysis.Skeletal radiology · 2025Pooled it
- Cryoablation for the Palliation of Painful Bone Metastasis: A Systematic Review.Cardiovascular and interventional radiology · 2023Pooled it
- Percutaneous microwave ablation of bone tumors: a systematic review.European radiology · 2021Pooled it
- The Roles of Magnetic Resonance-Guided Focused Ultrasound in Pain Relief in Patients With Bone Metastases: A Systemic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Percutaneous management of bone metastases: state of the art, interventional strategies and joint position statement of the Italian College of MSK Radiology (ICoMSKR) and the Italian College of Interventional Radiology (ICIR).La Radiologia medica · 2019Guideline
- Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial.Nature communications · 2024Trial
- Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma.Nature communications · 2021Trial
- 125I brachytherapy in the palliation of painful bone metastases from lung cancer after failure or rejection of conventional treatments.Oncotarget · 2016Trial
- An effective therapy to painful bone metastases: cryoablation combined with zoledronic acid.Pathology oncology research : POR · 2014Trial
- Magnetic resonance-guided focused ultrasound for patients with painful bone metastases: phase III trial results.Journal of the National Cancer Institute · 2014Trial
- Trial
- Personalizing Bone Tumor Ablation: Decision Models from the University Hospital of Strasbourg.Cardiovascular and interventional radiology · 2026Article
- Interventional Radiology in the Treatment of Musculoskeletal Tumours.Current oncology (Toronto, Ont.) · 2026Review
- Image-guided percutaneous interventions for bone tumors around the knee.Skeletal radiology · 2026Review
- Evaluation of the therapeutic efficacy of precise microwave ablation combined with spinal tumor separation surgery for managing spinal metastases.BMC musculoskeletal disorders · 2026Article
- Applications of spectral CT calcium suppression for percutaneous bone tumor ablation procedures.Radiology case reports · 2025Article
- Minimally Invasive Treatment Strategies for Metastatic Disease of the Skeleton: Current Concepts.Current oncology reports · 2025Review
- Interventional Therapies to Treat Cancer Associated Pain.Current treatment options in oncology · 2025Review
- State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines.Cancer metastasis reviews · 2025Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundThis study sought to describe the results of a single-arm multicenter clinical trial using image-guided percutaneous cryoablation for the palliation of painful metastatic tumors involving bone.
methodsOver a 44-month period, 61 adult patients with 1 or 2 painful bone metastases with a score of 4 or more on a scale of 0 to 10 (≥4/10) worst pain in a 24-hour period who had failed or refused conventional treatment were treated with percutaneous image-guided cryoablation. Patient pain and quality of life was measured using the Brief Pain Inventory prior to treatment, 1 and 4 days after the procedure, weekly for 4 weeks, and every 2 weeks thereafter for a total of 6 months. Patient analgesic use was also recorded at these same follow-up intervals. Complications were monitored. Analysis of the primary endpoint was undertaken via paired comparison procedures.
resultsA total of 69 treated tumors ranged in size from 1 to 11 cm. Prior to cryoablation, the mean score for worst pain in a 24-hour period was 7.1/10 with a range of 4/10 to 10/10. At 1, 4, 8, and 24 weeks after treatment, the mean score for worst pain in a 24-hour period decreased to 5.1/10 (P < .0001), 4.0/10 (P < .0001), 3.6/10 (P < .0001), and 1.4/10 (P < .0001), respectively. One of 61 (2%) patients had a major complication with osteomyelitis at the site of ablation.
conclusionsPercutaneous cryoablation is a safe, effective, and durable method for palliation of pain due to metastatic disease involving bone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.