ReviewCurrent psychiatry reports2012
An update on antidepressant use in bipolar depression.
Review in Current psychiatry reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Bright light therapy in the treatment of patients with bipolar disorder: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Serotonin 1A Receptor Binding of [11C]CUMI-101 in Bipolar Depression Quantified Using Positron Emission Tomography: Relationship to Psychopathology and Antidepressant Response.The international journal of neuropsychopharmacology · 2022Trial
- Assessment of treatment outcomes among bipolar patients at Mathari National Teaching and Referral Hospital, Kenya.BMC psychiatry · 2026Article
- Antidepressant treatment and risk of subsequent bipolar disorder in adolescents with unipolar depression.BMJ mental health · 2025Article
- Comparison of the efficacy of venlafaxine and bupropion in the treatment of depressive episode in patients with bipolar II disorder.Journal of family medicine and primary care · 2023Article
- Ketamine for bipolar depression: an updated systematic review.Therapeutic advances in psychopharmacology · 2023Article
- Bipolar depression: a review of treatment options.General psychiatry · 2022Review
- Bipolar depression: a major unsolved challenge.International journal of bipolar disorders · 2020Review
- Repetitive Transcranial Magnetic Stimulation in the Treatment of Bipolar Disorder.Therapeutic advances in psychopharmacology · 2020Review
- Clinical Role of Aspirin in Mood Disorders: A Systematic Review.Brain sciences · 2019Article
- Pharmacological treatment of adult bipolar disorder.Molecular psychiatry · 2019Review
- Antidepressants in bipolar depression: an enduring controversy.International journal of bipolar disorders · 2018Review
- Lamotrigine Therapy for Bipolar Depression: Analysis of Self-Reported Patient Data.JMIR mental health · 2018Article
- Bipolar disorder, comorbid anxiety disorders, gynecomastia and dental pain: case analysis with literature review.BJPsych open · 2018Article
- The difficult lives of individuals with bipolar disorder: A review of functional outcomes and their implications for treatment.Journal of affective disorders · 2017Review
- The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm.The international journal of neuropsychopharmacology · 2017Review
- Treatment response in relation to subthreshold bipolarity in patients with major depressive disorder receiving antidepressant monotherapy: a post hoc data analysis (KOMDD study).Neuropsychiatric disease and treatment · 2016Article
- Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.Molecular psychiatry · 2015Article
- Genetic variations within metalloproteinases impact on the prophylaxis of depressive phases in bipolar patients.Neuropsychobiology · 2014Article
- Treatment of bipolar disorder.Lancet (London, England) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effective treatment of depression in people with bipolar disorder remains a clinical challenge. The role of antidepressant medication in treating bipolar depression has been controversial. While early studies and meta-analyses supported a role for antidepressant medication, more recent, high quality randomized controlled trials in bipolar depression have generally not demonstrated efficacy for antidepressant medications. Although the risk of affective switch and long-term de-stabilization remains a concern when using antidepressant medications in bipolar disorder, the magnitude of this risk has been difficult to ascertain with confidence. Maintenance use of antidepressant medication has generally not demonstrated a favorable risk-benefit ratio. Future studies should explore the patient characteristics and response patterns that predict a more favorable response profile to antidepressants amongst patients with bipolar disorder so that the medications can be rationally used in those who are most likely to benefit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.