ArticleInternational urology and nephrology2013
Vitamin D deficiency, insulin resistance, serum adipokine, and leptin levels in peritoneal dialysis patients.
Article in International urology and nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Vitamin D and serum leptin: a systematic review and meta-analysis of observational studies and randomized controlled trials.European journal of clinical nutrition · 2017Pooled it
- The effects of short-term vitamin D supplementation on glucose metabolism in dialysis patients: a systematic review and meta-analysis.International urology and nephrology · 2015Pooled it
- Consumption of vitamin D-fortified yogurt drink increased leptin and ghrelin levels but reduced leptin to ghrelin ratio in type 2 diabetes patients: a single blind randomized controlled trial.European journal of nutrition · 2017Trial
- Effects of calcium-vitamin D co-supplementation on metabolic profiles in vitamin D insufficient people with type 2 diabetes: a randomised controlled clinical trial.Diabetologia · 2014Trial
- Association between Serum Adiponectin and Vitamin D in Obese Pre- and Early Postmenopausal Women: A Cross-Sectional Study.Journal of menopausal medicine · 2026Article
- Are serum leptin levels predicted by lipoproteins, vitamin D and body composition?World journal of diabetes · 2019Article
- Is There Any Relationship between Plasma 25-Hydroxyvitamin D₃, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?International journal of environmental research and public health · 2017Article
- The intriguing connections of leptin to hyperparathyroidism.Endocrine · 2017Review
- Serum 25-hydroxyvitamin D level and diabetic nephropathy in patients with type 2 diabetes mellitus.International urology and nephrology · 2015Article
- Peritonitis incidence was correlated with duration of peritoneal dialysis rather than leptin or neutrophil to lymphocyte (n/l) ratio in peritoneal dialysis patients.The Eurasian journal of medicine · 2014Article
- Leptin in chronic kidney disease: a link between hematopoiesis, bone metabolism, and nutrition.International urology and nephrology · 2014Review
- Confounded complexity: vitamin d, parathyroid hormone, and metabolic syndrome in peritoneal dialysis.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2014Article
- Associations between serum-intact parathyroid hormone, serum 25-hydroxyvitamin D, oral vitamin D analogs and metabolic syndrome in peritoneal dialysis patients: a multi-center cross-sectional study.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2014Article
- Association between Vitamin D and Adiponectin and Its Relationship with Body Mass Index: The META-Health Study.Frontiers in public health · 2014Article
- Obesity, adipose tissue function and the role of vitamin D.Central-European journal of immunology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAssociations between 25 hydroxy vitamin D [25(OH)D], adipokines levels, and insulin resistance have been reported. The aim of this study was to explore the effects of cholecalciferol supplementation on vitamin D levels, insulin resistance, leptin, and adiponectin levels in vitamin D-deficient peritoneal dialysis (PD) patients.
methodsIn nineteen vitamin D-deficient PD patients, who were treated with cholecalciferol, fasting serum glucose, insulin, adiponectin, leptin, 25(OH)D and parathyroid hormone (PTH) were measured before and after cholecalciferol replacement therapy. Eighteen (94.7 %) PD patients with vitamin D deficiency were receiving active vitamin D compounds (alphacalciferol) for PTH control. Alphacalciferol dosing was kept constant during treatment with cholecalciferol.
resultsWhile mean 25(OH)D significantly increased from (10.2 ± 4.9 ng/ml) to (82.9 ± 56.5 ng/ml) (p < 0.05), mean homeostatic model assessment-insulin resistance index significantly decreased from (4.6 ± 3.6) to (2.8 ± 2.0) after cholecalciferol replacement therapy (p < 0.05). Serum leptin levels (12.9 ± 17.6 ng/ml) significantly increased (18.1 ± 19.5 ng/ml) (p < 0.05), while there was no change in serum adiponectin, calcium, and phosphate after vitamin D replacement. Serum PTH levels significantly decreased from 551.9 ± 276.6 pg/ml to 434.0 ± 273.4 ng/ml.
conclusionsCholecalciferol replacement therapy significantly decreases PTH levels and insulin resistance. The results of this study need to be confirmed in larger clinical trials.
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