Evidence map›Paper›PMID 23065414›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012

Prognostic value of quantitative high-speed myocardial perfusion imaging.

Ryo Nakazato, Daniel S Berman, Heidi Gransar, Mark Hyun, Romalisa Miranda-Peats, Faith C Kite, Sean W Hayes, Louise E J Thomson, John D Friedman, Alan Rozanski and 1 more

Abstract readComparative Study
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. CZT camera systems may provide better risk stratification for low-risk patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  9. The indications and utility of adjunctive imaging modalities for chronic total occlusion (CTO) intervention.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  10. Article
  11. Observational
  12. Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Review
  13. Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Review
  14. Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Review
  15. Fully automated analysis of attenuation-corrected SPECT for the long-term prediction of acute myocardial infarction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  16. Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
  17. Predictors of high-risk coronary artery disease in subjects with normal SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
  18. Nuclear cardiology as it should look in the twenty-first century.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016
    Article
  19. Article
  20. Quantitative high-efficiency cadmium-zinc-telluride SPECT with dedicated parallel-hole collimation system in obese patients: results of a multi-center study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ryo NakazatoDepartment of Imaging, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Taper Building Suite 1258, Los Angeles, CA 90048, USA.
Daniel S Berman
Heidi Gransar
Mark Hyun
Romalisa Miranda-Peats
Faith C Kite
Sean W Hayes
Louise E J Thomson
John D Friedman
Alan Rozanski
Piotr J Slomka

Funding

Quantitative Prediction of Disease and Outcomes from Next Generation SPECT and CTR01HL089765 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SLOMKA, PIOTR J · 2007 to 2021
$6.1M
NHLBI NIH HHS HL089765NHLBI NIH HHS R01 HL089765
6 · The paper itself

Abstract

backgroundWe studied the prognostic value of fully automated quantitative analysis software applied to new solid-state, high-speed (HS) SPECT-myocardial perfusion imaging (MPI).

methods1,613 consecutive patients undergoing exercise or adenosine HS-MPI were followed for 2.6 ± 0.5 years for all-cause mortality (ACM). Automated quantitative software was used to compute stress total perfusion deficit (sTPD) and was compared to semi-quantitative visual analysis. MPI was characterized as 0% (normal), 1%-4% (minimal perfusion defect), 5%-10% (mildly abnormal), and >10% (moderately/severely abnormal).

resultsDuring follow-up, 79 patients died (4.9%). Annualized ACM increased with progressively increasing sTPD; 0% (0.87%), 1%-4% (1.94%), 5%-10% (3.10%), and >10% (5.33%) (log-rank P < .0001). While similar overall findings were observed with visual analysis, only sTPD demonstrated increased risk in patients with minimal perfusion defects. In multivariable analysis, sTPD > 10% was a mortality predictor (HR 3.03, 95% CI 1.30-7.09, P = .01). Adjusted mortality rate was substantial in adenosine MPI, but low in exercise MPI (9.0% vs 1.0%, P < .0001).

conclusionsBy quantitative analysis, ACM increases with increasing perfusion abnormality among patients undergoing stress HS-MPI. These findings confirm previous results obtained with visual analysis using conventional Anger camera imaging systems.

Indexed as

AdenosineAgedAged, 80 and overAlgorithmsCoronary Artery DiseaseExercise TestFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial Perfusion ImagingPrognosisRadiopharmaceuticalsAdenosineRadiopharmaceuticals

Identifiers

PMID23065414
PMCPMC3579769

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.