ArticleMolecular and cellular biochemistry2013
Crocin, a dietary additive protects platelets from oxidative stress-induced apoptosis and inhibits platelet aggregation.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 70 citations in OpenAlex.
- Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets.Journal of thrombosis and thrombolysis · 2014Trial
- Adverse Events of Saffron (Health science reports · 2026Article
- Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats.Neurochemical research · 2024Article
- Active constituents of saffron (Experimental and therapeutic medicine · 2023Review
- Natural phytochemicals prevent side effects inFrontiers in pharmacology · 2022Review
- Bleeding Complication in a Patient with Concomitant Use of Rivaroxaban and Saffron Supplement: A Case Report.Cardiovascular & hematological disorders drug targets · 2022Article
- Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats.Environmental science and pollution research international · 2021Article
- Scale-Up Preparation of Crocins I and II fromMolecules (Basel, Switzerland) · 2021Article
- Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review.Neurochemical research · 2020Review
- Effects and Mechanisms of Vitamin C Post-Conditioning on Platelet Activation after Hypoxia/Reoxygenation.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020Article
- Anticancer activities of phytoconstituents and their liposomal targeting strategies against tumor cells and the microenvironment.Advanced drug delivery reviews · 2020Review
- Crocin protects against dexamethasone‑induced osteoblast apoptosis by inhibiting the ROS/Ca2+‑mediated mitochondrial pathway.Molecular medicine reports · 2019Article
- Protective effect of crocin on ultraviolet B‑induced dermal fibroblast photoaging.Molecular medicine reports · 2018Article
- Novel sila-amide derivatives of N-acetylcysteine protects platelets from oxidative stress-induced apoptosis.Journal of thrombosis and thrombolysis · 2017Article
- Molecular Approaches to Genetically Improve the Accumulation of Health-Promoting Secondary Metabolites in Staple Crops-A Case Study: The Lipoxygenase-B1 Genes and Regulation of the Carotenoid Content in Pasta Products.International journal of molecular sciences · 2016Review
- Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases.Molecules (Basel, Switzerland) · 2015Review
- Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation.Scientific reports · 2015Article
- Treatment of Platelet Concentrates with the Mirasol Pathogen Inactivation System Modulates Platelet Oxidative Stress and NF-κB Activation.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2015Article
- Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats.EXCLI journal · 2015Article
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelets are the key players in the development of cardiovascular diseases as the microparticles generated by apoptotic platelets and platelet aggregation contribute actively towards the disease propagation. Thus, the aim of this study was to demonstrate the effect of a phytochemical which can prevent these two processes and thereby project it as a cardio-protective compound. Crocin, a natural carotenoid exhibits a wide spectrum of therapeutic potentials through its antioxidant property. The study demonstrated its effects on cytoplasmic apoptotic events of mitochondrial pathway in platelets. Collagen/calcium ionophore-A23187 stimulated platelets were treated with crocin and endogenous generation of reactive oxygen species (ROS) and hydrogen peroxide (H(2)O(2)) were measured. H(2)O(2)-induced changes in crocin-pretreated platelets such as intracellular calcium, mitochondrial membrane potential (ΔΨm), caspase activity, phosphatidylserine exposure and cytochrome c translocation were determined. Crocin dose-dependently ameliorated collagen- and A23187-induced endogenous generation of ROS and H(2)O(2). It also abolished the H(2)O(2)-induced events of intrinsic pathway of apoptosis. Further, it hindered collagen-induced platelet aggregation and adhesion. The current piece of work clearly suggests its anti-apoptotic effect as well as inhibitory effects on platelet aggregation. Thus, crocin can be deemed as a prospective candidate in the treatment regime of platelet-associated diseases.
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